浸润性导管癌原发灶CD3和CD20的表达与临床病理及预后指标的相关性分析

CD3 and CD20 Expressions of Original Site and the Correlation with Clinical Pathology and Prognosis Index in the Infiltrating Ductal Carcinoma

目的研究CD3^+和CD20^+淋巴细胞在浸润性导管癌原发灶中的表达及其与预后的关系。方法入组100例乳腺癌患者石蜡包埋病理标本,采用免疫组化法检测浸润性导管癌原发灶中CD3^+淋巴细胞、CD20^+淋巴细胞与临床病理及预后的关系。结果 100例乳腺癌患者原发灶中,CD3^+96例(96.0%),CD20^+54例(54.0%),原发灶CD3^+淋巴细胞的百分率与临床分期、组织学分级及淋巴结转移状态有关(P<0.05)。结论乳腺癌原发灶有淋巴细胞浸润,CD3^+与病变的严重程度密切相关。

Objective To research the CD3 and CD20 expressions and its relationship with prognosis in the primary infiltrating ductal carcinoma. Methods The 100 cases of breast carcinoma paraffin embedding pathologic specimens were collected,immunohistochemical detection was used to detect CD3^+lymphocytes,CD20^+lymphocytes in the primary infiltrating ductal carcinoma and the relationship with clinical pathology and prognosis. Results Of the100 cases of breast carcinoma,CD3^+for 96 cases( 96. 0%),CD20^+54 cases( 54. 0%),CD3^+lymphocyte infiltration was related with clinical stage,histological grade and lymph node status( P < 0. 05). Conclusion lymphocytes infiltration is mostly found in the breast carcinoma primary tumors,and CD3^+lymphocytes related to the degree of pathological changes.