黄芪注射液对早期糖尿病肾病患者临床症状及尿微量白蛋白的影响

Effect of Astragalus Injection on the Clinical Symptoms and Urinary Microalbumin in Patients with Early Diabetic Nephropathy

目的探讨黄芪注射液对早期糖尿病肾病(diabetic nephropathy,DN)患者临床症状及微量白蛋白水平的影响。方法选取作者医院2012-01/2013-12月收治的84例DN患者,根据随机数字表分为对照组及观察组各42例。对照组应用降糖药物及缬沙坦治疗,观察组在对照基础上应用黄芪注射液治疗,对比分析两组患者治疗效果。结果观察组总有效率为95.24%,对照组总有效率为83.33%,两组患者总有效率具有统计学意义(P<0.05)。观察组治疗后微量白蛋白(urine microalbumin,Umalb)、尿素氮(blood urea nitrogen,BUN)、血肌酐(serum creatinine,Scr)、尿红细胞(urine erythrocyte,RBC)显著低于对照组治疗后,差异有统计学意义(P<0.05)。观察组治疗后血清总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterin,LDL-C)低于对照组,而高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)则高于对照组,差异有统计学意义(P<0.05)。结论黄芪注射液能有效改善早期DN患者临床症状、血脂及尿微量白蛋白水平。

Objective To investigate the effect of astragalus injection on patients with early diabetic nephropathy.Methods A total of 84 DN patients in our hospital from January 2012 to December 2013 were divided into control group(n=42)and observation group(n=42).The control group were treated with antidiabetic drugs and valsartan.The observation group were treated with the above medicine plus astragalus injection.The therapeutic effects of the two groups were compared.Results The total effective rate of control group and observation group were 83.33% and 95.24%respectively which were significantly different(P<0.05).The levels of albumin(Umalb),blood urea nitrogen(BUN),creatinine(blood Scr),red blood cells in urine(urine RBC)of observation group were lower than those in the control group(P<0.05).The levels of erum total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)of observation group were lower than those in the control group,while high-density lipoprotein cholesterol(HDL-C)of observation group was higher than that of control group(P<0.05).Conclusion Astragalus injection can effectively improve the clinical symptoms of early DN and control the levels of lipids and urinary albumin.