80例特发性卵巢早衰相关危险因素调查与分析

Investigations of Related Factors in 80 patients with Idiopathic Premature Ovarian Failure

目的探讨导致特发性卵巢早衰(premature ovarian failure,POF)的相关危险因素及相关性研究,以期望为特发性POF的预防控制提供科学依据。方法选取符合诊断标准的特发性POF患者80例作为研究组,其他病人(内分泌疾病患者除外)和健康体检者中按1∶1的原则选择居住地区相同、卵巢功能正常、月经规则、基础性激素检查在正常范围内的80例作为对照组。对所采集的数据进行实证分析,并通过单因素以及多因素Logistic回归分析进行统计学处理。探究生活方式、生活习惯、个性特征以及生存环境等可能相关因素与特发性POF的相关性。结果特发性POF的相关危险因素包括A型行为性格、焦虑情绪、吸二手烟、激素使用、使用染发剂、接触有毒有害物质等。结论养成良好的生活习惯,重视个人身体健康,能够有效避免特发性POF的发生,早预防、早发现及早治疗以延缓疾病的发展。

Objective To investigate the related risk factors and correlation of idiopathic premature ovarian failure(POF)and provide scientific evidence for prevention and control of the idiopathic POF.Methods Eighty idiopathic POF patients were selected as observation group.Another 80 patients without endocrine disease or healthy cases in a 1∶1 ratio with the same residence,normal ovarian function,regular menstruation,basic sex hormone within the normal range were selected as control group.All data was collected with unified questionnaires and analyzed by single factor analysis and logistic regression model in order to investigate the correlation of life style,habits,personality characteristics and environment with idiopathic POF.Results The risk factors of idiopathic POF included the type A behavior,anxiety,secondhand smoking,hormone using,hair dye using,exposure to toxic and harmful substances,etc.Conclusins Culturing agood life style and emphasizing personal health can effectively avoid the occurrence of idiopathic POF.Early prevention,early detection and early treatment can postpone the progression of the disease.