研究IGF-Ⅰ、IGF-Ⅱ与ER、PR对子宫肌瘤的影响及其相关性

Influence of IGF-Ⅰ,IGF-Ⅱ and ER,PR and their Correlation in Leiomyoma of Uterus

目的探讨胰岛素样生长因子Ⅰ(insulin-like growth factorⅠ,IGF-Ⅰ)、胰岛素样生长因子Ⅱ(insulinlike growth factorsⅡ,IGF-Ⅱ)与雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)在子宫肌瘤发生、发展中的作用及其相关性。方法随机收集2012-03-01/2012-09-01日在作者医院住院因子宫肌瘤行子宫次全切除或子宫全切手术治疗患者30例,将30例患者术后标本根据研究分成子宫肌瘤组、肌瘤旁组织组、正常子宫肌层组、正常子宫内膜组共四大组。免疫组织化学法分别检测子宫肌瘤组、肌瘤旁组织组、正常子宫肌层组、正常子宫内膜组的IGF-Ⅰ、IGF-Ⅱ与ER、PR的表达水平,并对结果进行统计学分析。结果 IGF-Ⅰ、IGF-Ⅱ与ER、PR在子宫肌瘤组表达最高,肌瘤旁组织组中表达次之,在正常子宫肌层及正常子宫内膜中表达很低,差异有统计学意义(P<0.05)。另外,ER、PR的表达与IGF-Ⅰ、IGF-Ⅱ的表达呈相关性,结果具有统计学意义(P<0.05)。结论 IGF-Ⅰ、IGF-Ⅱ与ER、PR在子宫肌瘤发生、发展中起一定作用,其变化可影响ER、PR的表达。

Objective To study the effects and the correlation of IGF-Ⅰ(insulin-like growth factorⅠ),IGF-Ⅱ(insulin-like growth factorⅡ),ER and PR on leiomyoma of uterus.Methods A total of 30 cases on March1 st 2012 to September 1st 2012 of obstetrics and gynecology department in authors′hospital resections for leiomyoma of uterus were recepted surgical treatment,including subtotal hysterectomy and total hysterectomy.Postoperative specimens were divided into leiomyoma of uterus group,leiomyoma of uterus adjacent tissues group,normal myometrium group and normal endometrium group.The expression of IGF-Ⅰ,IGF- Ⅱand ER,PR of all groups were detected by immunohistochemistry,and the results were statistically analyzed.Results The highest expression of IGF-Ⅰ,IGF-Ⅱand ER,PR was in leiomyoma of uterus group,leiomyoma of uterus adjacent tissues took second place,almost no expression in normal myometrium and normal endometrium,the difference was statistically significant(P<0.05).In addition,the expression of ER and PR and expression of IGF-Ⅰ,IGF-Ⅱ were correlated,the results statistically significan(P<0.05).ConclusionIGF-Ⅰ,IGF-Ⅱand ER,PR play the important role in the occurrence,development of leiomyoma of uterus.The changes of IGF-Ⅰ and IGF-Ⅱ can influence the expression of ER and PR.