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2,5-吡嗪二甲酸的合成

Syntheses of 2,5-Pyrazinedicarboxylic Acid
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摘要 以2,5-二甲基吡嗪为原料,去离子水为溶剂,高锰酸钾为氧化剂在加热回流的条件下合成了2,5-吡嗪二甲酸。探讨了不同温度,氧化剂高锰酸钾用量,回流时间等因素对2,5-吡嗪二甲酸收率的影响。结果表明,当n(KMnO4)∶n(2,5-二甲基吡嗪)=5∶1,反应温度为80℃,回流时间为5 h时, 2,5-吡嗪二甲酸的收率达13.64%。 2,5-Pyrazinedicarboxylic acid was synthesized through heating and refluxing using 2,5-dimethylpyrazine as the starting materials,deionized water as solvent and potassium permanganate as oxidant.The reaction conditions were explored and determined as follows:the molar ratio of potassium permanganate to 2,5-dimethylpyrazine 5:1,reaction temperature around 80℃,the refluxing time 5 h.The yield of the topic compound was up to 13.64%.
作者 张志峰 张小青 郑素枚 柏瑶 陈思宇 ZHANG Zhi-feng;ZHANG Xiao-qing;ZHENG Su-mei;BAI Yao;CHEN Si-yu(Shenhua Baotou Coal Chemical Project Department Beijing Yanhua Zhengbang equipment maintenance Co.,Ltd.,Inner,Baotou 014060,China;College of Mechanical and Manufactural Engineering,Xiamen Institute of Technology,Xiamen 361021,China)
出处 《精细化工中间体》 CAS 2019年第2期70-72,共3页 Fine Chemical Intermediates
关键词 2 5-二甲基吡嗪 氧化 2 5-吡嗪二甲酸 2,5-dimethylpyrazine oxidization 2,5-pyrazinedicarboxylic acid
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