摘要
以2,5-二甲基吡嗪为原料,去离子水为溶剂,高锰酸钾为氧化剂在加热回流的条件下合成了2,5-吡嗪二甲酸。探讨了不同温度,氧化剂高锰酸钾用量,回流时间等因素对2,5-吡嗪二甲酸收率的影响。结果表明,当n(KMnO4)∶n(2,5-二甲基吡嗪)=5∶1,反应温度为80℃,回流时间为5 h时, 2,5-吡嗪二甲酸的收率达13.64%。
2,5-Pyrazinedicarboxylic acid was synthesized through heating and refluxing using 2,5-dimethylpyrazine as the starting materials,deionized water as solvent and potassium permanganate as oxidant.The reaction conditions were explored and determined as follows:the molar ratio of potassium permanganate to 2,5-dimethylpyrazine 5:1,reaction temperature around 80℃,the refluxing time 5 h.The yield of the topic compound was up to 13.64%.
作者
张志峰
张小青
郑素枚
柏瑶
陈思宇
ZHANG Zhi-feng;ZHANG Xiao-qing;ZHENG Su-mei;BAI Yao;CHEN Si-yu(Shenhua Baotou Coal Chemical Project Department Beijing Yanhua Zhengbang equipment maintenance Co.,Ltd.,Inner,Baotou 014060,China;College of Mechanical and Manufactural Engineering,Xiamen Institute of Technology,Xiamen 361021,China)
出处
《精细化工中间体》
CAS
2019年第2期70-72,共3页
Fine Chemical Intermediates