N-苯基苯甲醛缩氨基脲衍生物的合成研究

Synthesis of N-Phenyl-N-benzaldehyde Semicarbazone Derivatives

以氯甲酸苯酯和苯胺类化合物为原料,通过酰基化反应生成苯胺基甲酸苯酯类,然后与水合肼经肼解反应生成N-苯基缩氨基脲,最后与苯甲醛反应合成了N-苯基苯甲醛缩氨基脲衍生物。三步反应均在常温条件下完成,反应总收率80%以上,操作简单,适合工业化生产。

Anilinobenzoic acid phenyl esters were synthesized from phenyl chloroformate and aniline compounds.The obtained anilinobenzoic acid phenyl esters reacted with hydrazine hydrate to give N-phenyl semicarbazide.Finally,N-phenyl benzaldehyde semicarbazide derivatives were obtained by the reaction of N-phenyl semicarbazides with benzaldehyde.The results showed that this three-step reaction could performed at room temperature with a total yield of 84.7%.It is easy to operate and suitable for industrial production.