摘要
柯萨奇病毒A组16型(CoxsackievirusA16,CoxA16)病毒是引起手足口病(Hand,footandmouthdisease,HFMD)的主要病原体。为了解不同地区CoxA16病毒株的系统进化关系,收集了NCBI数据库中注释有具体地区分布的23条CoxA16全基因组序列,分别采用Kimura2-parameter法和E距离法对病毒株进行亲缘关系分析。结果表明,基于E距离的系统进化树最大程度地吻合了Kimura 2-parameter遗传距离法构建的系统进化树,且E距离法普适性较强,颇具应用潜力,为更精确地判断病毒株之间的进化关系提供了一条新途径。
Coxsackie virus A 16 (CoxA 16) is a major etiological agent of the hand, foot and mouth disease (HFMD) . To learn the phylogenetic relationship of CoxA 16 genomes from different regions, all genomes of CoxA 16 strains in NCB I were collected to construct genome phylogenetic trees based on Kim ura 2-param eter and E distance. The results show ed that the phylogenetic tree with E distance was the best fit to the one with Kim ura 2-parameter distance; and E distance with wide adaption had the potential to analyze phylogenetic relationship in CoxA16.This study willprovide a new method for CoxA16 evolution research.
出处
《湖南农业科学》
2014年第9期13-15,17,共4页
Hunan Agricultural Sciences
基金
国家自然科学基金青年项目(31301388)
湖南省自然科学基金(14JJ3092)
湖南省科学技术厅科技计划项目(2014GK3046)
湖南农业大学大学生创新性实验计划项目(71)
中国博士后面上项目(2014M562109)
