山莨菪碱辅助治疗暴发型流行性脑脊髓膜炎临床分析

Clinical analysis of ictus epidemic cerebrospinal meningitis treated by anisodamine

目的探讨山莨胆碱辅助治疗暴发型流行性脑脊髓膜炎(流脑)的临床效果。方法选择我院收治的68例暴发型流脑患者为研究对象,采用随机数字表法分为对照组和观察组。对照组采用常规综合治疗,观察组在对照组基础上加用山莨菪碱治疗。比较2组治疗效果及治疗过程中不良反应发生情况。结果观察组治疗5d后,总有效率、显效率均显著高于对照组,差异有统计学意义(P<0.05)。观察组病死率显著低于对照组,死于休克比例显著高于其他原因,差异有统计学意义(P<0.05)。观察组不良反应发生率显著低于对照组,差异有统计学意义(P<0.05)。结论山莨菪碱辅助治疗暴发型流脑安全可靠,疗效确切,值得临床推广应用。

Objective To study the clinical effect of anisodamine in the treatment of ictus epidemic meningitis .Methods Sixty-eight cases of ictus epidemic meningitis patients were chose as the research object ,and were randomly divided into control group and observation group by the random number table method .Conventional comprehensive therapy was used in the control group ,observation group was added anisodamine .Treatment effect and adverse reaction were observed .Results The total ef-fective rate and efficiency of the observation group after 5 days treatment were significantly higher than the control group ;the difference was statistically significant (P<0 .05) .The mortality of observation group was significantly lower than the control group .The ratio of died from shock was significantly higher than other reasons ,the difference was statistically significant (P<0 .05) .The incidence of adverse reactions of observation group was significantly lower than the control group ;the difference was statistically significant (P<0 .05) .Conclusion Anisodamine is safe and reliable in the adjuvant treatment of ictus epidemic meningitis with curative effect ,and if worthy of clinical application .