依达拉奉对急性脑出血患者炎性细胞因子水平及神经功能的影响

The effects of edaravone on the inflammatory cytokines and nerve function of patients with acute cerebral hemorrhage

目的研究依达拉奉对急性脑出血患者炎性细胞因子水平及神经功能的影响。方法 68例脑出血患者随机均分为实验组和对照组,对照组采用常规脱水药、抗生素等治疗,实验组在对照组基础上采用依达拉奉治疗。结果治疗7、14d,2组IL-1、IL-6、IL-8及TNF-α的水平有显著性差异,实验组IL-1、IL-6、IL-8及TNF-α的炎性因子的水平明显高于对照组(P<0.05)。治疗7、14d后,实验组NIHSS评分明显优于对照组(P<0.05),ADL评分明显高于对照组(P<0.01)。实验组总有效率(97.1%)明显高于对照组(76.5%),2组比较差异有统计学意义(χ2=14.2178,P=0.0026)。结论依达拉奉治疗脑出血疗效显著,可显著改善患者的炎性细胞因子水平。

Objective To study the effects of edaravone on the inflammatory cytokines and nerve function of patients with acute cerebral hemorrhage.Methods Sixty-eight cases with cerebral hemorrhage from March 2011 to March 2013 in our hospi-tal were studied and were randomly divided into experimental group and control group ,the control group were used with con-ventional dehydration drugs ,antibiotics ,the experimental group received edaravone based on the use of conventional thera-py.Results Before and after treatment ,comparative analysis of inflammatory cytokines of IL-1 ,IL-6 ,IL-8 and TNF-αlevels in patients of the two groups showed that on treatment of 7d ,14d ,the levels of IL-1 ,IL-6 ,IL-8 and TNF-αin patients of the two groups were significantly different ,the levels of IL-1 ,IL-6 ,IL-8 and TNF-α in patients of the experimental group were lower than those of the control group (P< 0.05).And the NIHSS scores were used to analyze the neurological damage of the two groups ,the result showed that after treatment of 7d ,14d ,the NIHSS scores of the experimental group score was significantly better than that of the control group(P<0.05).After treatment of 7d ,14d ,ADL score of the experimental group was signifi-cantly higher than that of the control group(P<0.01).After treatment ,the clinical efficacy of the two groups were compared and found that the total efficiency of experimental group (97.1% ) was significantly higher than that of the control group (76.5% ) ,the difference was statistically significant (χ2 =14.2178 ,P=0.0026).Conclusion Edaravone treatment for cerebral hemorrhage has a significant effectiveness and can significantly improve the patient's inflammatory cytokine levels.