地塞米松联合化疗与鞘内注射治疗急性淋巴细胞白血病脑神经损害的疗效

Curative efficacy of dexamethasone combined with chemotherapy and intrathecal injection on patients with acute lymphoblastic leukemia complicated with cranial nerve injury

目的探讨急性淋巴细胞白血病并发脑神经损害患者治疗中地塞米松联合化疗与鞘内注射的临床价值。方法选取2010—2013年我院收治的急性淋巴细胞白血病并发脑神经损害患者40例,随机分为2组,对照组行化疗与鞘内注射,研究组采用化疗与鞘内注射联合地塞米松治疗。结果治疗后研究组显效率、有效率与总有效率均明显高于对照组(P<0.05)。结论地塞米松联合化疗与鞘内注射能够有效改善急性淋巴细胞白血病并发脑神经损伤的疗效,同时无明显不良反应,值得临床应用。

Objective To investigate the clinical value of dexamethasone combined with chemotherapy and intrathecal injection on acute lymphoblastic leukemia complicated with cranial nerve injury.Methods 40 patients with acute lymphoblastic leukemia complicated with cranial nerve injury in our hospital from 2010-2013 were selected.The patients were divided into two groups,the control group was treated by chemotherapy and intrathecal injection,and the study group was treated by dexamethasone combined with chemotherapy and intrathecal injection.Results The effective rate,effective rate and total effective rate of the study group were significantly higher than those in the control group(P<0.05).Conclusion Dexamethasone combined with chemotherapy and intrathecal injection can effectively improve the therapeutic effect on acute lymphoblastic leukemia complicated with cranial nerve injury,and has no adverse reactions,which is worthy of clinical application.