高压氧治疗联合常规疗法对脑外伤患者认知功能障碍及预后的影响

Effect of hyperbaric oxygen therapy combined with conventional therapies on cognitive dysfunction and prognosis in patients with traumatic brain injury

目的探讨高压氧治疗与常规疗法合用对脑外伤患者认知功能障碍及预后的影响。方法选择2011-02—2013-05收治的100例脑外伤后认知功能障碍患者,对血清肿瘤标志物进行检测,根据随机数字表将其随机分成观察组及对照组各50例。对照组进行常规治疗,观察组在对照组治疗的基础上进行高压氧治疗,观察其效果。结果 2组治疗前NCSE评分对比,差异无统计学意义(t=0.933、0.492、0.843、0.509、0.483、0.309,P>0.05)。2组治疗后NCSE评分对比,差异有统计学意义(t=6.282、7.192、8.384、6.295、10.492、8.483、9.589,P<0.05)。2组治疗前FIM评分对比,差异无统计学意义(t=0.485、0.473、0.582、0.536、0.498、0.972,P>0.05)。2组治疗后FIM评分对比,差异有统计学意义(t=9.289、9.084、9.584、9.048、10.85、8.975、9.873,P<0.05);观察组疗效显著高于对照组,差异有统计学意义(χ2=8.392,P<0.05)。结论对脑外伤认知功能障碍患者以高压氧治疗后,能够显著降低脑外伤疾病的发生率,改善患者的预后及认知功能。

Objective To investigate the effect of hyperbaric oxygen therapy combined with conventional therapies on cog‐nitive dysfunction and prognosis in patients with traumatic brain injury.Methods 100 cases of patients with traumatic brain in‐jury and cognitive dysfunction were selected from February 2011 to February 2013 ,and were divided into the observation group and control group. Patients in the control group were treated with routine treatment. Patients in the observation group were treated by hyperbaric oxygen therapy on the basis of control group. The effect was observed.Results Compared with the con‐trol group ,NCSE score in observation group before treatment had no statistically significant differences (t= 0.933 ,0.492 , 0.843 ,0.509 ,0.483 ,0.309 ,P>0.05);after treatment ,NCSE score had statistically significant differences between the two groups (t=6.282 ,7.192 ,8.384 ,6.295 ,10.492 ,8.483 ,9.589 ,P<0.05). Compared with the control group ,FIM scores in observation group had no differences (t= 0.485 ,0.473 ,0.582 ,0.536 ,0.498 ,0.972 , P> 0.05);after treatment ,FIM scores had statistically significant differences between the two groups (t=9.289 ,9.084 ,9.584 ,9.048 ,10.85 ,8.975 ,9.873 , P<0.05). The efficacy of observation group was significantly higher than that of control group ,the difference was statistically significant (χ2 = 8.392 , P< 0.05).Conclusion Hyperbaric oxygen in the treatment of traumatic brain injury patients with cognitive dysfunction ,can significantly reduce the incidence of traumatic brain injury ,and improve the prognosis and cognitive function.