糖化血红蛋白及血脂与急性缺血性脑卒中伴脑微出血的相关性研究

Correlative study of brain microhemorrhage glycosylated hemoglobin and blood lipids associated with acute ischemic stroke

目的探讨糖化血红蛋白(HbA1c)及血脂与急性缺血性脑卒中伴脑微出血(CMBs)的相关性。方法选择2013-02—2014-02收治的120例急性缺血性脑卒中患者,根据是否伴脑微出血分为观察组(伴CMBs)65例,对照组(无CMBs)55例,对比2组的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、APO-A1、APO-B和HbA1c等生化指标含量,并进行相关性回归分析。结果观察组总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白、APOA1、APO-B、HbA1c水平均与对照组有所差异,但仅TC及HbA1c差异明显,即TC水平低于对照组,HbA1c水平高于对照组,差异有统计学意义(P<0.05);伴脑微出血的急性缺血性脑卒中患者,SWI检查显示CMBs位置主要位于基底节区,占50.8%,患者年龄主要分布在65~80岁(72.3%)阶段,明显高于45~65岁阶段,差异有统计学意义(P<0.05)。结论糖化血红蛋白及胆固醇水平与急性缺血性脑卒患者发生脑微出血存在一定的相关性,两者是产生脑微出血现象的危险因素。

Objective To analyze the correlation of brain microhemorrhage glycosylated hemoglobin and blood lipids associated with acute ischemic stroke.Methods One hundred and twenty acute ischemic stroke patients from February 2013 to February 2014 were selected,and were divided into trail group(with CMBs,65cases)and control group(without CMBs,55cases).The level of total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL),high density lipoprotein(HDL),APO-A1,APO-B and HbA1 cand other biochemical markers of two group were compared,and they were analyzed by correlation regression.Results HbA1 clevel of trail group was higher than that of control group(P<0.05),TC level of trail group was lower than that of control group(P<0.05);SWI displayed that CMBs of trail lied in basal ganglia mostly,and patients in trail group age were 65-80 years mostly,which were higher than the patients with 65-80 years old(P<0.05).ConclusionBrain microhemorrhage certain correlation between glycated hemoglobin and cholesterol levels and stroke in patients with acute ischemic brain occurs,both of which are risk factors for cerebral microhemorrhage produce phenomena.