IL-6TNF-a用于高血压脑出血早期预警分级的可行性分析

Feasibility analysis of IL-6 and TNF-αapplied in early warning grading of hypertensive cerebral hemorrhage

目的分析白细胞介素-6(IL-6)、肿瘤坏死因子-a(TNF-a)用于高血压脑出血早期预警分级的可行性,为高血压脑出血的治疗及预防提供参考。方法选取2013-09—2015-03我院收治的高血压患者90例为研究对象,高血压伴脑出血者纳入A组(45例),单纯高血压者纳入B组(45例),采用双抗体夹心法(ELISA)测定发病后第1天、3天、7天、15天血清IL?6及TNF-a水平,并应用受试者工作特征曲线(ROC曲线)统计分析IL-6、TNF-a水平对高血压脑出血早期分级预测价值。结果发病后1d、3dA组IL-6、TNF-a水平较B组显著升高(P<0.05),第7天、15天2组IL-6、TNF-a水平均下降(P<0.05);ROC曲线分析显示血清IL-6、TNF-a浓度对高血压脑出血早期分级均具有显著预测价值,且其预测价值比较无显著差异(P>0.05)。结论 IL-6、TNF-a可作为高血压脑出血早期预警分级指标,值得在临床广泛应用。

Objective To analyze the feasibility of interleukin-6(IL-6)and tumor necrosis factor-alpha(TNF?α)applied in early warning grading of hypertensive cerebral hemorrhage,and to provide reference for the treatment and prevention of hypertensive cerebral hemorrhage.Methods Ninety cases of hypertensive patients treated in our hospital between September2013 and March 2015 were selected as the study subjects.Hypertensive patients with cerebral hemorrhage were included in group A(45cases),and patients with hypertension alone were included in group B(45cases).The levels of serum IL-6and TNF?αwere determined by double mono-cloned antibody(ELISA)on the 1st,3rd,7th and 15 th day after attack.The receiver operating characteristic curve(ROC curve)was used to statistically analyze the value of levels of IL-6and TNF?αin predicting early grading of hypertensive cerebral hemorrhage.Results The levels of IL-6and TNF?αin group A were significantly higher than those in group B on the 1st and 3rd day after attack(P<0.05).On the 7th and 15 th day,the levels of IL?6and TNF?αin the two groups decreased(P<0.05);ROC curve analysis showed that the levels of serum IL-6and TNF?αhad significant predictive value in early staging of hypertensive cerebral hemorrhage,and there was no significant difference in predictive value(P>0.05).ConclusionIL-6and TNF?αcan be used as early warning and grading index of hypertensive cerebral hemorrhage.