阿托伐他汀联合疏血通注射液对急性脑梗死患者血脂水平和颈动脉粥样硬化斑块的影响

The influences of Atorvastatin combined with ShuXueTong injection on blood lipid level in patients with acute cerebral infarction and on carotid atherosclerotic plaque

目的观察使用阿托伐他汀联合疏血通注射液治疗急性脑梗死对血脂水平与颈动脉粥样硬化斑块的影响。方法选取2011-05—2014-08收治的急性脑梗死患者116例,随机分为观察组与对照组,对照组单纯使用阿托伐他汀治疗,观察组在对照组基础上联合疏血通注射液治疗,对比观察2组治疗后血脂水平与颈动脉粥样硬化斑块的影响。结果观察组治疗后血脂检测总胆固醇、甘油三酯、低密度脂蛋白水平明显低于对照组,高密度脂蛋白水平则高于对照组(P<0.05);与对照组相比,观察组治疗后颈动脉内-中膜厚度较薄、粥样硬化斑块面积与数量显著减少,差异均具有统计学意义(P<0.05)。结论对急性脑梗死患者在使用阿托伐他汀基础上联合疏血通注射液进行治疗,可有效改善血脂水平与颈动脉局部状况,减少、稳定颈动脉粥样硬化斑块,具有理想的临床应用效果及价值。

Objective To research the influences of atorvastatin combined with ShuXueTong injection on blood lipid levelin patients with acute cerebral infarction and on carotid atherosclerotic plaque.Methods We selected 116 cases with acute cerebral infarction from May 2011 to August 2014 and randomly divided them into observation group and control group.Patients in the control group were treated with pure atorvastatin therapy,and patients in the observation group received ShuXueTong injection combined with atorvastatin.After treatment,blood lipid levels and the detection of carotid atherosclerotic plaques in two groups were comparatively analyzed.Results The levels of total cholesterol,triglyceride,low density lipoprotein in the observation group were significantly lower than that in the control group,while the level of high density lipoprotein was higher than that in control group(P<0.05);Compared with the control group,after treatment,the observation group had thinner carotid intimal-media thickness(IMT),smaller area of atherosclerotic plaque and less number of plaques,with statistically significant differences(P<0.05).Conclusion The application of ShuXueTong injection on the basis of atorvastatin can effectively improve the blood lipid levels and local condition of carotid artery,can stabilize carotid atherosclerotic plaques,which should be worthy of ideal clinical application.