^(35)S-丙硫苯咪唑合成工艺路线

SYNTHESIS OF [^(35)S]-ALBENDAZOLE

本文描述了广谱驱虫剂^(35)S-两硫苯咪唑的合成方法。它是由元素^(35)S 和氰化钾反应生成^(35)S-硫氰化钾开始,经过五步合成完成。总放化收率20%,比放射性7.59mCi/mM,放化纯度94.5%。

The vermifuqe 5(6)-propylthio-carbomethoxyaminobenzimidazole (Albendazole)was labelled with ^(35)S in propylthio group.The synthesis was accomplished in five steps starting with ^(35)S element and potassium cyanide as shown in scheme.The radiochemical yield was 20%.The specific activity was 7.59 mCi/mM.