瑜伽对乳腺癌化疗患者癌因性疲乏的干预效果

Effect of Yoga on cancer related fatigue in breast cancer patients with chemotherapy

目的:了解乳腺癌化疗患者癌因性疲乏状况,探讨瑜伽对患者癌因性疲乏的干预效果。方法:制作乳腺癌患者康复瑜伽;采用癌症疲乏量表(cancer fatigue scale,CFS)将第2次入院化疗且存在疲乏(CFS总分>0)的乳腺癌患者100例随机分为实验组和对照组各50例。对照组给予乳腺科常规治疗护理,实验组除常规治疗护理外进行有规律的瑜伽练习,为期4个月,于第2,4,6次化疗时收集患者CFS评价情况,比较两组癌因性疲乏的状况。结果:最终有效病例82例,其中实验组40例,对照组42例。82例患者躯体疲乏得分(12.67±3.46)相对较高,干预前两组的CFS总分及3个维度得分差异均无统计学意义(P>0.05);干预后第4次化疗实验组疲乏总分、躯体疲乏得分均低于对照组,差异有统计学意义(P<0.05);干预后第6次化疗实验组疲乏总分、躯体疲乏得分、认知疲乏得分均低于对照组,差异有统计学意义(P<0.05);重复测量方差分析发现两组患者总体疲乏、躯体疲乏、认知疲乏得分的干预主效应差异有统计学意义(P<0.05),总体疲乏、躯体疲乏、情感疲乏得分的时间主效应差异有统计学意义(P<0.05),总体疲乏、躯体疲乏、认知疲乏得分的干预因素与时间因素存在交互作用(P<0.05)。结论:乳腺癌化疗患者躯体疲乏较重,瑜伽干预能有效缓解乳腺癌化疗患者的躯体疲乏和认知疲乏,从而降低总体疲乏程度。

Objective:To evaluate the condition of cancer-related fatigue(CRF) in breast cancer patients with chemotherapy and to explore the effect of Yoga on it.Methods:After the completion of Yoga,100 breast cancer patients with CRF(CFS>0) were selected and were randomly divided into the Yoga group and the control group(n=50).Patients in the control group only received routine cure and care while patients in the Yoga group received extra Yoga exercise,lasting for 4 months.Cancer fatigue scale(CFS) was evaluated in the 2nd,4th and 6th round of chemotherapy.Results:At the end,82 cases qualified for the study,42 cases for the control group and 40 for the Yoga group.The mean score of body fatigue was 12.67±3.46.There was no significant difference in CRF between the Yago group and the control group before the Yoga intervention(P>0.05).After the 4th round of chemotherapy,the mean scores of CFS and body fatigue in the Yoga group were significantly lower than that in the control group(P<0.05).After the 6th round of chemotherapy,the mean scores of CFS,body fatigue and cognitive fatigue in the Yoga group were lower than that in the control group(P<0.05).Repeated analysis of variance showed that the difference in the overall fatigue,body fatigue and cognitive fatigue between the Yoga group and the control group was significant(P<0.05);the time influence on the overall fatigue,body fatigue and emotional fatigue was significant difference between the 2 groups(P<0.05);there were interactions between the effect of Yago and time on the overall fatigue,body fatigue and cognitive fatigue(P<0.05).Conclusion:The body fatigue was more serious in breast cancer patients with chemotherapy.Yoga intervention could significantly reduce body fatigue,cognitive fatigue,thus reduce the overall fatigue in breast cancer patients with chemotherapy.