Sagliker综合征1例报道并文献复习

A case of Sagliker syndrome and literature review

回顾性分析1例典型Sagliker综合征患者,并结合国内外文献进行分析,发现Sagliker综合征发病率低,发病年龄轻,常见于女性,原发病为非糖尿病性肾病者通常为慢性肾小球肾炎,血液中存在高水平碱性磷酸酶和甲状旁腺激素,继发性甲状旁腺功能亢进多由甲状旁腺增生所致。继发性甲状旁腺功能亢进患者血液中高水平碱性磷酸酶和甲状旁腺激素是引起Sagliker综合征的主要原因。甲状旁腺切除手术治疗可以阻制Sagliker综合征的进展,但不能逆转已发生的骨骼畸型。

We analyzed the characters of Sagliker syndrome by reporting a case of Sagliker syndrome and reviewed literature.We found that Sagliker syndrome had low incidence rate,young onset age,and was more common in women.There were high levels of alkaline phosphatase and parathyroid hormone in the blood of the patients.Patients with Sagliker syndrome with primary onset of non-diabetic nephropathy usually had chronic glomerulonephritis.We thought that secondary hyperparathyroidism in patients with Sagliker syndrome was induced by parathyroid hyperplasia,but high levels of alkaline phosphatase and parathyroid hormone in the blood of the patients with the secondary hyperparathyroidism were the main cause of Sagliker syndrome.Parathyroidectomy could stop the progress of Sagliker syndrome,but it could not reverse the occurrence of skeletal malformation.