银杏叶提取物治疗急性脑梗死的系统评价

System evaluation on Ginkgo Biloba extract in the treatment of acute cerebral infarction

目的:系统评价银杏叶提取物治疗急性脑梗死的疗效和安全性。方法:检索万方数据库、中国知网数据库及维普数据库等,收集已公开发表的有关银杏叶提取物治疗脑梗死的临床随机对照试验的相关文献,按照预先设计的要求筛选文献、选取资料和质量评估后,采用Revman 4.2软件对文献中的原始研究进行系统评价。结果:与对照组比较,银杏叶提取物组疗效显著提高,总有效率比值比(odds ratio,OR)为1.60~5.53,神经功能缺损评分加权均数差(weighted mean diff erence,WMD)为-3.12(95%CI:-3.96^-2.28)。结论:银杏叶提取物有益于改善急性脑梗死患者的神经功能缺损状况,安全性好。

Objective: To evaluate the effect and safety of Ginkgo Biloba extract on the treatment of acute cerebral infarction.Methods: The Database of Wanfang, China National Knowledge Infrastructure(CNKI) and VIPU were screened for literatures regarding Ginkgo Biloba extract in the treatment of acute cerebral infarction, including the clinical randomized controlled trials. Meta-analysis based on the Revman 4.2 system was performed.Results: Compared with the control group, treatment with Ginkgo Biloba extract enhanced ef f icacy in the treatment of acute cerebral infarction(OR: 1.60–5.53), which displayed an improved neural function defect score [WMD –3.12(95%CI: –3.96– –2.28)].Conclusion: Ginkgo Biloba extract is benefi cial to the improvement of neurological function in patients with acute cerebral infarction and it is safe for patients.