盆底功能障碍性疾病的多因素分析

Multivariate analysis for pelvic floor dysfunction

目的:探讨盆底功能障碍性疾病的相关危险因素。方法:选取2007年1月至2013年12月于郑州大学第三附属医院盆底重建科行盆底重建术的患者346例为盆底功能障碍性疾病组,体检的健康女性349例为对照组。分别记录其孕产次数、绝经史、子宫切除术手术史、子宫肌瘤病史及白带常规结果。结果:盆底功能障碍性疾病组有子宫切除术史、绝经史、白带常规清洁度≥III度及阴道乳酸杆菌缺乏的患者例数明显高于对照组(P<0.05);盆底功能障碍性疾病组孕次和产次均明显高于对照组(P<0.05)。其中子宫切除手术史、孕次、产次及阴道乳酸杆菌的缺乏是盆底功能障碍性疾病的独立危险因素。结论:有子宫切除术史、孕产次数多、白带常规清洁度≥III度及阴道乳酸杆菌缺乏可能参与了盆底功能障碍性疾病的发生发展,而阴道内乳酸杆菌的存在可能是盆底功能障碍性疾病的保护性因素。

Objective: To investigate the risky factors for pelvic floor functional disorder. Methods: A total of 346 patients, who undergone surgery for pelvic floor reconstruction from January 2007 to December 2013 in the Third Affiliated Hospital of Zhengzhou University, were enrolled for this study and served as an experimental group. Meanwhile, 349 female healthy subjects were selected as a control group. The data including the times of gestation and parity, history of menopause, hysterectomy surgery, uterine fibroid and leucorrhea were recorded. Results: Compared with the controls, the numbers of people with hysterectomy, menopause and clean vagina≥III degree, lack of lactobacillus as well as the times of gestation and parity in the experimental group were significantly increased(P<0.05). The history of hysterectomy, the times of gestation and parity and lack of lactobacillus in vagina were the independent risk factors of pelvic floor dysfunction.Conclusion: The history of hysterectomy, the times of gestation and parity, and clean vagina may involve in the occurrence and development of pelvic floor functional disorder, and the existence of lactobacillus in the vagina might be a protective factor.