ACS患者血清血尿酸、同型半胱氨酸及脂联素水平与冠状动脉病变的关系

The relationship between serum uric acid in blood of patients with ACS,homocysteine,adiponectin and coronary artery disease

目的:检测急性冠脉综合(ACS)征患者外周血清血尿酸(SUA)、同型半胱氨酸(HCY)、脂联素(ANP)水平及冠脉病变支数的关系。方法:选择住我院心内科经CAG诊断的患者共170人,其中ACS组(n=97)、SUA组(n=36)和NCHD组(n=37)。以ELISA分别测定患者外周血清SUA、HCY及ANP水平;冠脉病变支数根据CAG评定。结果:1、ACS组患者外周血清SUA、HCY及ANP水平与NCHD组和SA组患者水平比较有统计学意义。ACS患者外周血清SUA、HCY及ANP水平与冠脉病变支数比较差异有统计学意义。结论:l、ACS组患者外周血清SUA、HCY及ANP水平表明可能与冠脉易损斑块的病理生理相关。2、ACS患者外周血清SUA、HCY及ANP水平与冠脉病变支数有统计学意义,进一步提示它们外周血清水平的升高可能与冠状动脉粥样硬化发生发展相关。

Objective The detection of acute coronary syndrome (ACS) patients with peripheral serum uric acid ( SUA ), homocysteine ( HCY ), adiponectin (ANP) levels and coronary artery lesion count. Methods Choose to live in Department of Cardiology of our hospital was diagnosed with CAG 170, ACS group ( n=97 ), SA group ( n=36 ) and group NCHD ( n=37 ). ELISA were detected in the peripheral serum SUA, HCY and ANP levels;coro-nary lesion vessels according to CAG evaluation. Results 1 patients in the ACS group, serum SUA, HCY and ANP levels in group NCHD and group SA were compared the level of statistical significance ( P<0.05 ). There was statistical significance in ACS patients peripheral serum levels of SUA, HCY and ANP levels and coronary artery lesion count difference ( P<0.05, P<0.01 ). Conclusion 1, ACS groups of patients with serum SUA, HCY and ANP levels that may be related to the pathophysiology of coronary vulnerable plaque. There was statistical significance in 2, ACS in peripheral serum SUA, HCY and ANP levels and coronary lesion vessels, further sug-gesting the level of their peripheral serum group with coronary atherosclerosis development.