D-二聚体和C反应蛋白对急性肠系膜缺血患者诊断和预后评估的临床意义

Clinical significance of C-Reactive Protein and D-Dimer in diagnosis and prognosis of Acute Mesentedearte Isehemia

目的:探讨急性肠系膜缺血患者D-二聚体和C反应蛋白水平变化对诊断和预后评估的作用及临床意义。方法:2010年10月～2012年10月25例AMI患者为研究对象,即AMI组;同期25例其它急腹症患者为对照,即非AMI组;同期25例健康体检者为正常对照组。25例AMI患者根据起病时间和临床表现分为进展组和症状缓解组。分别比较AMI组和非AMI组、正常对照组,进展组和缓解组CRP和D-二聚体水平及变化。结果:AMI组患者D-二聚体较非AMI组、正常对照组明显升高,差异有统计学意义。进展组AMI患者D-二聚体较症状缓解组低,但进展组升高趋势明显;进展组AMI患者CRP总体水平和缓解组无明显差异。结论:D-二聚体和CRP水平变化联合检测对AMI的早期诊断,尽早治疗和改善预后有重要临床意义。

Objective To investigate the role of D-Dimer and C-Reactive Protein (CRP) in diagnosis and prognosis of Acute Mesentedearte Isehemia (AMI). Methods From October, 2010 to October, 2012, 25 AMI pa-tients as the research subject (AMI Group);25 acute abdominal patients and 25 healthy persons in the same peri-od as the control group (non-AMI Group) and normal control group (NC Group). 25 AMI patients were divided into progressive group and relief group according to the morbidity time and clinical manifestations. Compare the levels and changes of D-Dimer and CRP among AMI Group, non-AMI group and NC Group; compare the changes and trend of D-Dimer and CRP between progressive group and relief group. Results The level of D-Dimer in patients of AMI Group was significantly higher than non-AMI Group and normal control group. Though increased significantly in 24 h, the level of D-Dimer in patients of progressive Group was lower than relief Group. The comparison of levels of CRP between progressive Group and relief Group shows no significant difference. Conclusion Increased levels of D-Dimer and CRP can be considered as diagnostic parameters for AMI, with sig-nificant value in guidance of treatment and improvement of prognosis.