儿童呼吸道腺病毒感染临床分析

Clinical analysis 98 cases of respiratory adenovirus infected children

目的:总结儿童呼吸道腺病毒感染的临床特点和治疗经验。方法:收集住院治疗的98例腺病毒感染患儿,对其临床表现、实验室检查、影像学资料、治疗经过等资料进行回顾整理、综合分析。结果:呼吸道腺病毒感染各年龄段均可发病,无明显性别差异。临床表现主要有发热、球结膜充血、扁桃体上白色渗出物、颈部淋巴结肿大、咳嗽、喘息、精神萎靡等;早期白细胞升高以中性粒细胞为主,可有C反应蛋白(CRP)、血沉(ESR)、降钙素原(PCT)升高。结论:儿童呼吸道腺病毒感染,发热持续时间较长,临床表现多样,早期大多数患儿的炎性指标升高,腺病毒感染后引起的全身炎症反应较其他病毒感染更重,可合并其他微生物感染,重症病例应尽早使用糖皮质激素和静脉人免疫球蛋白,必要时可行肺泡灌洗等综合治疗。

Objective Summarize clinical features and treatments experience of children with respiratory adenovirus infection. Methods Review and analysis clinical features, laboratory examinations, image findings, therapeutic process and etc, in 98 cases of respiratory adenovirus infected and hospitalized children. Results Respiratory adenovirus infects children all ages and no gender differences. Main clinical features is fever, con-junctiva hyperemia, white exudates on tonsils, cervical lymph node enlargement, cough, wheeze, depression;Lab-oratory examinations:In the early stage, white blood cell count was high and mainly neutrophile granulocyte and could be accompanied elevation of CRP, ESR and PCT. Conclusion Children with respiratory adenovirus infec-tion have long fever time, various clinical features and may be combining with other microbes' infection. Their inflammation markers are elevated at early stage. As severe pneumonia cases, intravenous glucocorticoids and hu-man immunoglobulin should be administered as soon as possible, comprehensive treatments such as bronchial tube pulmonary alveolus fills washes could be applied if necessary.