丁苯酞软胶囊对帕金森伴抑郁患者的协同治疗作用观察

Observation on the Therapeutic Effect of Butylphthalide Soft Capsules for the Patients with Parkinson Combined with Depression

目的:探讨丁苯酞治疗帕金森合并抑郁的临床疗效及对血清神经营养因子-3(NT-3)、急性反应蛋白(CRP)的影响。方法:选取自2012年1月1日~2013年4月30日来我院接受治疗的帕金森合并抑郁60例,按入院顺序随机分为对照组和丁苯酞实验组,每组30例。对照组给予常规治疗,丁苯酞实验组在常规治疗的基础上给予丁苯酞软胶囊,治疗时间12周。治疗前后采用HAMD、UPDRS评分评价临床疗效。并检测两组患者治疗前后血清NT-3、CRP水平。结果:经12周治疗后,两组患者血清CRP水平、HAMD、UPDRS评分均较治疗前明显降低,而NT-3水平较治疗前明显升高。丁苯酞实验组HAMD、UPDRS评分下降比对照组更明显。结论:采用丁苯酞治疗帕金森合并抑郁具有良好的疗效,可明显降低血清CRP、升高NT-3水平并改善抑郁症状。

Objective To observe the therapeutic effect of butylphthalide in the treatment of patients with Parkinson combined with depression,and the influence on the Neurotrophin-3( NT-3) and acute reaction protein.Methods Sixty patients with Parkinson combined with depression in our hospital from Jan1,2012 to April 2013were randomly divided into the butylphthalide treated group( 30 cases) and the control group( 30 cases). The control group was treated with common therapeutic regime,while butylphthalide treated group was given butylphthalide soft capsula beside common therapeutic regime for 12 weeks. All patients were respectively examed by the HAMD and UPDRS scores before and after the treatment,and the serum level of NT-3 and CRP was assayed. Results After12 weeks of the treatment,The HAMD,UPDRS scores and the level of CRP in the serum reduced compared with that of before the treatment,while the serum level of NT-3 increased. The butylphthalide treated group showed a significant effect more than that of control group. Conclusion Butylphthalide can improve the clinical symptoms for patients with Parkinson combined with depression as well as regulating the serum level of NT-3 and CRP.