糖尿病慢性并发症患者护骨素水平分布及调脂干预研究

Distribution of Serum Osteoprotegerin in Chronic Complicated Type 2Diabetic Patients and Changes After Lipid-Lowering Therapy

目的:探讨2型尿病和以及不同并发症患者血清护骨素(OPG)水平及调脂治疗前后其水平的比较。方法:新诊断的2型糖尿病以及合并神经病变、视网膜病变和冠心病患者各50例,另选年龄性别相匹配的50例健康者为对照组,采用ELISA法检测不同组血清OPG水平;比较辛伐他汀治疗2周后护骨素水平的变化。结果:血清同型半胱氨酸和护骨素水平在2型糖尿病及不同并发症组明显高于对照组,而且DMCVD组与DM组之间存在显著差异。调脂治疗2周后护骨素水平比较无显著差异。结论:血清护骨素在新发2型糖尿病组以及合并神经、视网膜和冠心病组患者中明显升高,与血糖控制指标相关。

Objective To explore the levels of serum osteoprotegerin in type 2 diabetes and with different complicationsandtheeffectoflipid-loweringtherapy.Methods 50casesofNewly-diagnosedtype2diabetesand diabetic neuropathy , retinopathy and coronary heart disease , 50 healthy people in gender and age matched control group, ELISA method was used to detect the level of serum OPG in different groups;Changes in levels of OPG after 2 weeks of simvastatin treatment .Results The serum homocysteine and osteoprotegerin levels in type 2 diabetes mellitus and different complications groups were significantly higher than that in control group , and there was signif-icant difference between group DMCVD and group DM .Serum osteoprotegerin levels showed no significant differ-ence after 2 weeks of Lipid-lowering therapy .Conclusion Serum osteoprotegerin in Newly-diagnosed type 2 diabe-tes and diabetic neuropathy , retinopathy and coronary heart disease groups were significantly increased and associ -ated with glycemic control index .