血清降钙素原对间质性肺病合并感染诊断价值分析

Diagnosis Analysis of Serum Procalcitonin on Interstitial Lung Disease Combined with Infections

目的:探讨降钙素原在结缔组织病所致间质性肺病合并肺部感染早期预测作用及临床价值。方法:选取2011年1月至2014年5月我院确诊结缔组织病所致间质性肺病伴发热患者120例,其中痰培养阳性、痰培养阴性但胸部CT有典型影像学改变且对规范抗生素治疗有效归为细菌感染组(n=80),其余患者归为非细菌感染组(n=40),两组都进行了C-反应蛋白(CRP)和降钙素原(PCT)的检测,同时进行了常规白细胞(WBC)水平和中性粒细胞百分率(N)的检测。结果:细菌感染组的血清CRP与PCT值明显高与非细菌感染组,而两组的WBC与N含量水平对比差异无统计学意义。CRP与PCT水平与结缔组织病所致间质性肺病患者细菌感染的发生具有正向相关性。CRP与PCT诊断结缔组织病所致间质性肺病发生细菌感染的ROC曲线下面积明显高于WBC与N,对比差异都有统计学意义。结论:血清降钙素原对间质性肺病合并感染有一定的诊断价值,能早期、特异、敏感地鉴别细菌感染与非细菌感染,值得推广应用。

Objective To investigate the early prediction and clinical value of procalcitonin on interstitial lungdiseasecombinedwithinfections.Methods 120caseswithinterstitiallungdiseasecombinedwithinfections from Jan.2011 to May 2014 in our hospital were chosen , the cases with sputum culture positive , or sputum culture negative but typical chest CT images changes and standardized antibiotic treatment effective were classified as the bacterial infection group ( n=80 ) , others were classified as non-bacterial infection group ( n=40 ) , two groups were given C-reaction protein (CRP) and procalcitonin (PCT) detection, and at the same time, who were given conven-tional leukocyte (WBC) level and neutrophils percentage (N) detection.Results The serum CRP and PCT val-ues of bacterial infection were obviously high than non-bacterial infections group , and WBC and N level of two groups had no statistical differences .CRP and PCT levels were positive correlation with bacterial infection of patients with interstitial lung diseases caused by connective tissue disease .The ROC area under the curve of CRP and PCT diagnosis on interstitial lung diseases caused by connective tissue diseases were significantly higher than WBC and N, which had statistically differences .Conclusion Serum procalcitonin had value of diagnosis on interstitial lung diseases combined infections , which could early , specific and sensitively identification of bacterial infections and non-bacterial infections , which should be widely applied .