丁桂儿脐贴预防儿童静滴阿奇霉素时的胃肠反应

Influence of Topical Ding Guier Umbilical Paste in Adverse Reactions of Intravenous Infusion of Azithromycin in Infants and Young Children

目的:探讨外用丁桂儿脐贴在婴幼儿静滴阿奇霉素时所致不良反应的影响。方法:200例使用阿奇霉素治疗的患呼吸道疾病而无肠胃疾病及大便异常的婴幼儿(均无大环内酯类药物过敏),分为实验组和对照组,两组均控制输液速度和用药前避免空腹,将≤3岁患儿滴速调节为8~16滴/min,实验组静滴该类药物前30 min使用丁桂儿脐贴。观察两组静脉滴注阿奇霉素所致肠胃不良反应的发生情况。结果:对照组组不良反应的发生率明显高于实验组,经χ2检验,差异有统计学意义。结论:丁桂儿脐贴的使用显著减轻了婴幼儿静滴阿奇霉素时所致的肠胃刺激。

Objective To investigate the influence of topical Ding Guier umbilical paste in adverse reactions of intravenous infusion of azithromycin and erythromycin ( microcline antibiotics ) in infants and young children Methods 200cases,whowerenotallergictoabovemedicines,wereselectedwithrespiratorydiseasesandwith-out gastrointestinal problems or abnormal bowel movements in Children Medical Center of our hospital from February to September of 2013 , They were randomly divided into the experimental group and the control group , 100 cases in each group, there were 42 infants(25 males) and 58 young children(38males) in experimental group, there were 41 infants(25males) and 59 young children (36 males ) in control group, The transfusion speed was controlled well and fasting was avoided before the transfusion for both groups , the fluid was given at a speed of less than or e-qual to 8 to 16 drops per minute for children under 3 .Two groups were observed for gastrointestinal adverse reac-tions of microcline antibiotics .Results The incidence rate of adverse reactions was significantly higher in the con-trol group than in the experimental group , the difference was statistically significant by χ2 test.Conclusion Ding Guier umbilical paste significantly reduce the rate of gastrointestinal irritation caused by intravenous infusion of mi -crocline antibiotics in infants and small children .