糖代谢因素与良性前列腺增生临床进展的相关性

Study on the Correlation of Metabolic Factor of Glucose and Clinical Progession of Benign Prostatic Hyperplasia

目的:探讨糖代谢因素对老年人良性前列腺增生症(BPH)临床进展的影响。方法:117例老年BPH患者将年龄≥62岁、PSA≥1.6ng/m L、PV≥31m L分为高进展性组(60人),其余为低进展性组(57人),分析比较两组间空腹血糖(FBS)、餐后2小时血糖(2h PBG)、糖化血红蛋白(Hb A1c)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)等代谢性因素及BPH患者PV、血清前列腺特异性抗原(PSA)、国际前列腺症状评分(IPSS)、下尿路症状(LUTS)出现时间;用Logistic回归分析BPH临床进展性的危险因素。结果:BPH高进展性组与BPH低进展性组的FBS、2h PBG、Hb A1c、FINS相比有差异;且BPH高进展性组患者的PV明显大于BPH低进展性组患者,PSA值升高、IPSS分值增加;用Logistic逐步回归分析方法筛查BPH进展性危险因素,显示FBS、FINS为BPH患者临床进展的危险因素。结论:FBS、FINS可促使老年BPH患者的临床进展。

Objective To investigate the affect of glucose metabolism in clinical progession of elderly benign prostatichyperplasia(BPH).Methods 117casesofBPHpatientsagedover62years,PSAover1.6ng/mL,PV over 31 mL named high progressive group ( 60 people ) , and the remained named low-progressive group ( 57 peo-ple ) the two groups were analyzed and compared , between fasting blood glucose ( FBS) , 2-hour postprandial glu-cose (2hPBG), glycated hemoglobin (HbA1c), fasting insulin (FINS), insulin resistance index (HOMA-IR) and other metabolic factors and BPH patients PV , serum prostate-specific antigen ( PSA), International Prostate Symptom Score ( IPSS) , lower urinary tract symptoms ( LUTS) appear time;Logistic regression analysis of clinical progression of BPH risk factors .Results There are significant differences between the two groups on FBS、2hPBG、HbA1 c、FINS;the PV on high progressive group was significantly greater than the low , PSA increased , IPSS scores increased;Logistic regression analysis screening the risk factors for BPH progress which display FBS , FINS both are the risk factors to BPH clinical progression in patients .Conclusion FBS, FINS can contribute to clinical pro-gression in elderly patients with BPH .