药物性肝损伤35例临床特点分析

Clinical characteristics analysis of 35 patients with drug-induced liver injury

目的 :探讨引起药物性肝损伤(DILI)的药物种类及其临床特点。方法 :回顾性总结我院近10年DILI住院患者的临床资料,分析其使用药物、临床表现、肝损害及治疗转归。结果 :35例DILI中男12例,女23例,男女比例为1∶1.9。平均年龄53.5±15.0岁,其中55岁及以上者占57.1%。引起肝损伤的药物中,中药17例,西药18例,降脂药、抗生素和抗肿瘤药为引起DILI前三位的西药。男性患者的GGT水平明显高于女性患者,55岁以下患者的ALT水平明显高于55岁及以上年龄组。结论 :中药引起的DILI不容忽视,DILI好发于中老年女性,在使用具有潜在肝损伤的药物时需格外谨慎。

Objective To investigate the clinical features of drug-induced liver injury(DILI). Methods Thirty-five DILI patients were studied retrospectively. Results Among the 35 patients, 12 cases were males, 23 cases were females, the maleto-female ratio was 1∶1.9; and age of 55 and above accounts for 57.1%. The leading cause of DILI was traditional Chinese medicine, which was followed by lipid lowering drugs, antibiotics and antineoplastic agents. GGT level of male patients was significantly higher than that of female patients, and ALT level of patients under 55 years of age was significantly higher than that of patients above 55 years of age. Conclusion The DILI caused by traditional Chinese medicine cannot be ignored, and the injury is more common in elderly women which should be paid more attention.