重组人干扰素-γ联合激素治疗特发性肺间质纤维化患者临床研究

Observe Curative Effect of Recombinant human interferon combined with hormone in the treatment of idiopathic pulmonary interstitial fibrosis patients

目的 :观察重组人干扰素-γ(IFN-γ)联合激素治疗特发性肺间质纤维化(Idiopathic pulmonary fibrosis,IPF)患者的疗效。方法 :临床纳入IPF患者100例,根据患者入院后治疗方案的不同分为研究组与对照组,研究组给予IFN-γ联合激素治疗,对照组仅给予激素治疗。观察治疗前后两组患者Ⅲ型胶原(Collagen TypeⅢ,Ⅲ-C)、IV型胶原(Collagen Type IV,IV-C)、透明质酸(Hyaluronic acid,HA)水平;此外,观察两组患者治疗前后临床症状、胸部CT、肺弥散功能等指标的变化。结果 :治疗前,两组患者Ⅲ-C、IV-C、HA水平差异均未见显著性;治疗后,研究组Ⅲ-C、IV-C、HA水平分别为(49.57±4.31)ng/m L、(64.39±17.98)ng/m L、(79.01±22.84)ng/m L,对照组Ⅲ-C、IV-C、HA水平分别为(80.36±5.09)ng/m L、(73.33±18.94)ng/m L、(90.944±21.67)ng/m L,差异均有显著性;研究组患者呼吸困难、刺激性干咳、活动能力以及肺弥散功能好转率分别为52.0%、56.0%、60.0%、64.0%,对照组分别为24.0%、24.0%、28.0%、32.0%,差异均有显著性。结论 :IFN-γ联合激素治疗IPF,能够有效改善患者呼吸困难、刺激性干咳等临床症状,改善其活动能力以及肺弥散功能,且能够有效改善肺纤维化的程度,值得推广。

Objective To observe the effects of recombinant human interferon gamma(IFN- gamma) combined with hormone in the treatment of idiopathic pulmonary interstitial fibrosis(Idiopathic pulmonary, fibrosis, IPF) patients. Methods Clinical IPF patients were included 100 cases, according to the treatment after the patient is admitted to hospital, they were divided into study group and control group, the research group were treated by IFN-gamma ray combined hormone therapy, the control group only received hormone therapy. The two groups were observed before and after treatment of type III collagen(Collagen Type III,Ⅲ-C) and collagen type IV(Collagen Type IV, IV-C), hyaluronic acid(Hyaluronic, acid, HA) level; in addition, to observe the changes of the two groups before and after treatment in patients with clinical symptoms, chest CT, pulmonary diffusion function index. Results Before treatment, III-C, IV-C, HA levels of patients in the two group showed no significant difference; after the treatment, the study group III-C, IV-C, HA levels were(49.57±4.31) ng/m L,(64.39±17.98) ng/m L,(79.01±22.84) ng/m L, the control group III-C, IV-C, HA levels were(80.36±5.09) ng/m L,(73.33±18.94) ng/m L,(90.944±21.67) ng/m L, there was significant difference; the study group of patients with dyspnea, irritating cough, activity and pulmonary diffusion function improvement rate were 52%, 56%, 60% and 64%, control group were 24%, 24% 28% and 32%, respectively, there was significant difference. Conclusion IFN- gamma ray combined with hormone therapy for IPF can effectively improve the patients with dyspnea, irritating cough and other symptoms, improve its activity ability and pulmonary diffusion function, and which can improve the degree of pulmonary fibrosis, it is worthy of promotion.