培门冬酶在儿童急性淋巴细胞白血病诱导化疗中的应用研究

Analysis of toxicity and efficacy of chemotherapy pegaspargase and L-asparaginase acute lymphoblastic leukemia

目的 :探讨儿童急性淋巴细胞白血病诱导化疗中培门冬酶与左旋门冬酰胺酶的毒副作用以及治疗效果。方法 :从本院2009年2月~2014年2月收治的儿童急性淋巴细胞白血病患者中随机选择95例进行研究,随机分为对照组(47例)和观察组(48例),分别给予左旋门冬酰胺酶和培门冬酶治疗。观察两组的毒副反应发生情况以及治疗效果,并进行比较。结果 :两组在治疗总缓解率和毒副反应发生率方面经比较差异无统计学意义;但观察组的住院时间显著短于对照组,用药次数显著少于对照组,经比较差异均有统计学意义。结论 :儿童急性淋巴细胞白血病诱导化疗过程中,利用培门冬酶和左旋门冬酰胺酶进行治疗均能获得一定的治疗效果,并导致一定毒副作用的出现,但培门冬酶治疗在用药次数和住院时间方面存在明显的优势。

Objective To explore the toxicity and efficacy of chemotherapy pegaspargase and L-asparaginase acute lymphoblastic leukemia. Methods 95 cases of children with acute lymphoblastic leukemia patients in our hospital from February 2013 to February 2014 were selected,and were divided into control group(47 cases) and observation group(48 cases),and were given L-asparaginase and pegaspargase treatment. Adverse reaction incidence and treatment effect of the two groups were observed and compared. Results The two group in the treatment of total response rate and adverse reaction rate was no significant difference.The hospitalized days; but group was significantly shorter than that in the control group, the number of drugs was significantly less than that in the control group, the difference was statistically significant. Conclusion Children with acute lymphocytic leukemia during induction chemotherapy, the use of pegaspargase and L-asparaginase treatment can obtain certain curative effect, and lead to some side effects, but the pegaspargase treatment has obvious advantages in times of medication and hospitalization time.