舌下含服米索前列醇治疗不全流产疗效分析

Clinical analysis of sublingual misoprostol for incomplete abortion

目的 :比较米索前列醇和期待疗法对不全流产的临床疗效。方法 :将99例B超确诊为不全流产的患者随机分为试验组50例和对照组49例,试验组患者给予米索前列醇片400μg舌下含服,对照组只进行临床观察。结果 :试验组和对照组完全流产率分别为87.50%和84.78%,出血时间、腹痛时间和妊娠囊排出时间两组均无明显差异;两组满意度组间比较差异无统计学意义,但完全流产患者的满意度高于非完全流产患者;所有患者入组时的心理创伤程度相当,至研究结束两组GHQ评分组间比较差异无统计学意义。结论 :米索前列醇和期待疗法治疗不全流产效果相当,临床上可根据需要选择。

Objective To compare the clinical efficacy of misoprostol and expectant treatment for incomplete abortion. Methods 99 incomplete abortion patients diagnosed by ultrasound were divided into test group(n=50) and control group(n=49) randomly. The test group adminstered sublingual 400μg misoprostol tablets and control group adminstered clinical observations only. Results Complete abortion rates of test group and control group were 87.50% and 84.78% respectively. There was no significantly difference in duration of vaginal bleeding, duration of abdominal pain, time to pass tissue mass and satisfaction between two groups. But satisfaction of complete abortion patients were higher than non-complete abortion patients. All patients got psychological impact at baseline, but there was no significant difference between two groups in GHQ scores at last. Conclusions Quite misoprostol and expectant treatment for incomplete abortion effect, clinical on can choose according to need.