2型糖尿病胰岛素注射患者夜间低血糖的血糖水平及药物调整效果探讨

To investigate the blood glucose level and the effect of insulin dose adjustments in treating nocturnal hypoglycemia of type 2 diabetes

目的 :分析2型糖尿病患者夜间低血糖的发生情况,探讨胰岛素减量降低夜间低血糖风险的可行性。方法 :120例住院2型糖尿病患者列入调查,比较调整剂量并加用阿卡波糖组(观察组)与单用胰岛素不加用阿卡波糖组(对照组)的血糖水平;观察组患者应用调整方案治疗10d,对比调整方案前、后的夜间低血糖发生情况。结果 :观察组患者的夜间血糖平均值显著低于对照组;观察组患者调整胰岛素治疗方案之后的夜间低血糖发生率低于调整前。结论 :住院2型糖尿病患者检测夜间血糖水平有助于预测夜间低血糖的发生,胰岛素适当减量联合阿卡波糖口服有助于降低夜间低血糖的风险,值得临床进一步研究。

Objective To analyze the relationship between the occurrence of nocturnal hypoglycemia and quantitative indicators in patient with type 2 diabetes. And explore the feasibility of reducing risk of nocturnal hypoglycemia by reducing insulin dose. Method: 120 hospitalized patients with type 2 diabetes were included in the survey. The quantitative indicators of the observation group and the control group were compared then. The observation group took insulin adjustment program for 10 days. Then compare the occurrence of nocturnal hypoglycemia before and after the treatment. Results The mean nighttime blood glucose of the observation group was significantly lower than that of the control group. After the treatment of insulin dose adjustment, the incidence of nocturnal hypoglycemia in the observation group was lower than before. Conclusion: Detect nighttime glucose levels may predict the occurrence of nocturnal hypoglycemia of hospitalized patients with type 2 diabetes. Appropriate reduction of insulin combined with acarbose helps reduce risk of nocturnal hypoglycemia.