血管肌纤维母细胞瘤与侵袭性血管粘液瘤临床病理特征

Aggressive Angiomyxoma and Angiofibroblastoma: Clinical treatments and pathological analysis

目的 :探讨外阴血管肌纤维母细胞瘤(AMFB)与侵袭性血管粘液瘤(AAM)的临床、病理特点。方法 :回顾性分析我院2002年2月~2014年2月收治的2例侵袭性血管粘液瘤患者以及11例血管肌纤维母细胞瘤患者的临床资料,对所有患者的免疫组化结果以及临床病理学特点进行分析和总结。结果 :患者的肿瘤病灶多出现于右侧的大阴唇上,所有患者的瘤体直径在1~4cm之间,平均直径为2.1±0.8cm。两组患者经局部切除术进行治疗,术后为期1年的随访均未出现复发。两类肿瘤镜下均以间质瘤细胞和丰富的血管成分为主。结论 :侵袭性血管粘液瘤以及外阴血管肌纤维母细胞瘤患者在临床表现、病理学变化,治疗方法等方面均存在一定的区别,临床上需要依据病理细胞学以及免疫组化方法进行鉴别诊断。

Objective To analysis and discuss the vulva of the clinical,pathological features angiomyofibroblastoma(AMFB) and aggressive angiomyxoma(AAM).Methods A retrospective analysis of our hospital in February 2002 to February 2014 admitted 2 cases of aggressive angiomyxoma patients and 11 cases vascular myofibroblastic tumor patients clinical data,the results of immunohistochemistry and clinical pathological features were analyzed and summarized.Results Of all 2 cases of aggressive angiomyxoma,1 patients with first diagnosed,the remaining 1 patients relapse within a year after surgical treatment,11 cases of vascular myofibroblastic tumor patients were primary diagnosed,statistics show that the patient’s tumor lesions appeared on the right side of the labia majora,all the diameter of tumor patients between 1-4cm,average diameter was 2.1±0.8cm,this study for the patients of aggressive angiomyxoma in adopting a rice area of local excision for treatment,and vulva angiomyofibroblastoma patients were treated by local excision,followed up for 1 years after the two groups of patients for recurrence.Two types of tumors were all with stromal tumor cells and abundant blood based components,origin of interstitial myofibroblasts or fibroblasts,under the mirror was more difficult to distinguish,immunohistochemistry to identify some help.Conclusion The results of this study show that aggressive angiomyxoma and vulva angiomyofibroblastoma changes in patients with clinical manifestations,pathology,treatment methods and other aspects exist the difference between a point,according to pathology,cytology and immunohistochemistry method for differential diagnosis of clinical.