抗抑郁焦虑药物辅助治疗胃食管反流病的临床研究

Clinical research of antidepressant and antianxiety drug in the treatment gastroesophageal reflux disease

目的 :探讨抗抑郁焦虑药物辅助治疗治疗胃食管反流病的临床效果及安全性。方法 :将我院2012年11月~2014年10月期间收治的166例胃食管反流病患者平均分成实验组和对照组两组,每组83例,对照组采用雷贝拉唑治疗,实验组在此基础上予以抗焦虑抑郁药物氟哌噻吨美利曲辛进行治疗。对比两组患者的症状积分、临床疗效及不良反应。结果 :治疗结束后,实验组患者的各项症状积分均明显低于对照组,临床总有效率显著高于对照组,两组之间的不良反应发生率无统计学差异。结论 :抗抑郁焦虑药物辅助治疗胃食管反流病的临床效果良好、安全性高,具有广泛的应用前景。

Objective To explore the clinical value and safety of antidepressant and antianxiety drug in the treatment gastroesophageal reflux disease. Methods 166 patients with gastroesophageal reflux disease who got medical treatment in our hospital were divided into experimental group and control group, each group had 83 patients. Patients in control group were cured with rabeprazole, simultaneously, patients in experimental group were treated with rabeprazole combined with flupenthixol melitracen. Compare the symptom score, curative effect and adverse reaction of these two groups. Results After therapy, various symptom score of experimental group were significantly lower than control group, the clinical total effective rate was marked better than control group, these was no difference in adverse reaction between the two groups. Conclusion Antidepressant and antianxiety drug has excellent effect and high safety in the treatment of gastroesophageal reflux disease, so it possess broad application prospects in clinical practice.