半乳凝素3在不稳定心绞痛诊疗中的临床价值研究

The value of Galectin-3 in the diagnosis of unstable angina

目的 :分析半乳凝素3(Gal-3)在不稳定心绞痛诊疗中的临床价值。方法 :分析2012年1月~2014年1月在我院接受诊疗的冠心病患者的临床资料。依据患者冠心病的疾病状态分为2组,观察组(不稳定性心绞痛)及对照组(稳定性心绞痛)。结果 :本研究共纳入患者96例,其中观察组46例,对照组50例。观察组患者血清CRP显著高于对照组;观察组患者血清Gal-3水平显著高于对照组。Pearson相关性检验显示,观察组患者血清CRP与Gal-3呈现显著正相关关系,具有统计学意义。ROC曲线分析显示,当Gal-3取值为5.87ng/m L时预测敏感性为91.30%,特异性为92.00%,优于CRP。结论 :半乳凝素3可用以辅助诊疗不稳定心绞痛。

Objective Our study was aimed toanalyze the value of Galectin-3(Gal-3) in the diagnosis of unstable angina. Methods Clinical data of patients with coronary heart disease received treatment at ourhospitalfrom 2012 to 2014 was analyzed. Patients were divided into two groups by the disease activity state, Group A: Unstable angina; Group B:stable angina. ResultsA total of 96 patients were analyzed, Group A46 cases, Group B 50 cases. Group A patients had higher levels of CRP and Gal-3than these of Group B patients, the difference was statistically significant(P<0.05). Correlation analysis showed that, for Group A patients, the levels of CRP had significant positive correlation with Gal-3(t=0.813,P<0.001). ROC analysis showed that the Gal-3 cut-off point value of 5.87ng/ml, as used for the diagnosis of unstable angina, provided a sensitivity of 91.30%, a specificity of 92.00%, better than these of CRP. Conclusion Gal-3 can be used as a diagnosis index of unstable angina for patients with coronary heart disease.