普拉洛芬眼药水在青光眼手术前后炎症控制的临床评价

Clinical evaluation Pranoprofen glaucoma eye drops before and after surgery inflammation control

目的 :在青光眼手术前后使用普拉洛芬眼药水并对其疗效及临床价值进行研究,探究疗效好的治疗方案。方法 :选取我院2014年1月~2014年12月收治的青光眼患者98例(98眼)作为研究的对象,所有患者均接受青光眼小梁切除术治疗。将这98例患者随机分成4组:A组患者在术后使用典必殊眼药水进行治疗,B组患者在术后联合使用普拉洛芬眼药水和典必殊眼药水进行治疗,C组患者术前1天始用普拉洛芬眼药水、术后采用联合用药方法,D组患者术前3 d始用普拉洛芬眼药水、术后采用联合用药方法。结果 :D组在术后的第1、3和7天评分均要显著低于其他3组;A组在术后第3、7天综合评分要明显高于其他3组;术后第15、30天,4组间评分无明显差异。4组患者的闪辉值在治疗后均呈现下降趋势,且D组手术后3、7、15、30天闪辉值均要显著低于A组A组术后30天的闪辉值则要显著高于B组、C组;4组患者的最终疗效间比较无明显差异。结论 :青光眼患者术前始用普拉洛芬眼药水,并在术后将之与典必殊眼药水联用是控制患者术后炎症的极佳方案,可以在临床上推广使用。

Objective Our retrospective study was aimed to analyze the efficacy and clinical value of using eye drops Pranoprofen before and after glaucoma surgery. Methods Clinical data of patients received treatment at our hospital from January 2014 to December 2014 was retrospectively analyzed. Patients included were divided into four groups according to the treatment: patients in group A ofusing eye drops for treatment in the postoperative Tobra Dex, Patients in group B using of eye drops Pranoprofen and eye drops Tobra Dex treatment after surgery,patients in group C one day before surgery beginning with eye drops Pranoprofen, after surgery using the combination method,patients in group D three days before the beginning of eye drops with pranoprofen, after using the combination method. Results D group were significantly lower than the other three groups in postoperative scores 1, 3 and 7 days; A group at seven days after surgery composite score was significantly higher than the other three groups; 15, 30 days after the first, scoring four groups had no significant difference. Flare value of four groups of patients after treatment showed a downward trend, and Group D after surgery 3,7,15,30 day flare values were significantly lower than in group A; A flare group after 30 days will have a value significantly higher than group B, group C; there was no big difference in efficacy between the final four groups of patients. Conclusion Glaucoma patients with eye drops Pranoprofen at the beginning, and in the post with the use of eye drops Tobra Dex will be associated controlled postoperative inflammation.Excellent scheme can be extended to use in clinical practice.