三联疗法治疗消化性溃疡的临床分析及预后分析

The clinical analysis and prognostic analysis of the triple therapy to peptic ulcer

目的 :研究左氧氟沙星、泮托拉唑、克拉霉素三联疗法治疗消化性溃疡的疗效及预后情况。方法 :选取我院2012年3月~2014年3月接诊的120例消化性溃疡患者作为研究对象,按入院顺序将他们分为对照组和观察组,各60例。对照组采用奥美拉唑联合克拉霉素以及甲硝唑片治疗;观察组则采用左氧氟沙星、泮托拉唑、克拉霉素三联疗法治疗。调查分析两组患者的幽门螺杆菌(Hp)根除情况及不良反应,并评定两组患者治疗后的溃疡愈合情况。结果 :对照组的愈合总有效率为80.00%,而观察组的愈合总有效率为93.33%,两组比较差异具有统计学意义。观察组患者治疗后Hp根除的比例明显高于对照组,两组比较差异具有统计学意义。对照组的不良反应发生率为28.33%,而观察组仅为6.67%,观察组的不良反应发生率明显低于对照组,两组比较差异具有统计学意义。结论 :左氧氟沙星、泮托拉唑、克拉霉素三联疗法治疗消化性溃疡的临床效果良好,可有效根除Hp,并且不良反应少。

Objective To study the efficacy and prognosis of Levofloxacin, pantoprazole and clarithromycin triple therapy to peptic ulcer. Methods 120 cases peptic ulcer patients in our hospital from March 2012 to March 2014 were studied, and they were divided into the control group(March 2012 to March 2013) and the observation group(April 2013 to March 2014) according to the order of their admission, each 60 cases. The control group was treated with omeprazole combined with clarithromycin and metronidazole tablets; and the observation group is used with Levofloxacin, pantoprazole and clarithromycin triple therapy to treat. Analyzed the Helicobacter pylori(Hp) eradication and adverse reactions of the two groups, and assessed the ulcer healing of patients after treatment. Results The ulcer healing total effective rate in the control group was 80.00%, while the ulcer healing total effective rate of the observation group was 93.33%, and the difference was statistically significant. The proportion of Hp eradication of the observation group after treatment was significantly higher than the control group, and the difference was statistically significant. the adverse reactions occurrence rate of the control group was 28.33%, while the observation group was only 6.67%. And the incidence of adverse reactions of the observation group was significantly lower than the control group, the difference was statistically significant. Conclusion Levofloxacin, pantoprazole and clarithromycin triple therapy has good clinical effect to treat peptic ulcer and can eradicate effectively Hp,and adverse reactions were small.