京津冀地区不同妊娠时期甲状腺功能指标比较研究

Comparision study of thyroid function test results of Beijing-tianjin-hebei region in 458 cases pregnant women in the different pregnancy period

目的 :比较研究京津冀地区458例不同妊娠时期甲状腺功能指标。方法 :选取既往无甲状腺病史、B超检测无甲状腺结节的妊娠妇女(妊娠组)458例作为研究对象,采用罗氏电化学发光法检测游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、血清促甲状腺素(TSH)、绒毛膜促性腺激素(HCG)水平。另选取同期450例非妊娠育龄妇女作为对照研究(对照组)。结果 :1妊娠组甲状腺疾病发生率66.59%高于对照组20.52%;2妊娠早期FT3、FT4与对照组比较,差异无统计学意义,TSH明显低于对照组;妊娠中、晚期FT3、FT4水平明显低于对照组,TSH明显高于对照组;3 h CG与孕妇TSH呈负相关。结论 :京津冀地区孕妇甲状腺疾病发生率较高,且妊娠中晚期FT3、FT4明显降低,TSH明显升高。

Objective To compared study thyroid function index of Beijing-tianjin-hebei region in 458 cases pregnant women in the different pregnancy period Methods 458 cases pregnant women with no thyroid history and thyroid nodule was selected as the research object (pregnant group), used roche electrochemical luminescence method tested free three-triiodothy-ronine (FT3) and free thyroxine (FT4), serum thyrotropin (TSH), (HCG) level. selected 450cases of pregnancy women of child-bearing age as control study (control group). Results ①Pregnancy group thyroid diseases (66.59%) was significantly higher than the control group(20.52%); ②There were no statistically difference of FT3, FT4 in early pregnancy between two groups, TSH was significantly lower than the control group; Mid and late pregnancy group FT3, FT4 level were significantly lower than the control group, TSH was significantly higher than the control group; ③HCG and negatively correlated with pregnant women TSH. Conclusion Beijing-tianjin-hebei region pregnant women thyroid diseases was higher,middle-late pregnancy FT3、FT4 sig-nificantly lower, TSH significantly increased.