影像学联合多项肿瘤标志物对肺癌误诊率的影响

The impact of pulmonary imaging combined with multiple tumor markers onmisdiagnosis rate of lung cancer

目的:探析肺癌患者的早期诊断中多种肿瘤标志物和肺部影像学联合检测的临床意义。方法:分析在我院接受治疗的150例肺癌患者的临床资料,选取同期在我院就诊的70例良性疾病患者作为本次实验的肺良性病组,另外选取同期来院体检的52例健康体检者作为本次研究的对照组。比较三组患者的5种肿瘤标志物的检测结果、血清肿瘤标志物的敏感度和特异度以及各项指标联合检测敏感度。结果:肺癌组患者的血清NSE、CEA及CYFRA21-1的水平均比肺良性病组和对照组患者高,肺癌组的SCC值比对照组高。各肿瘤标志物的特异度均较高;CEA的敏感度(63.8%)最高,其次是CYFRA21-1(44.1%);CEA的阴性、阳性预测值均最高,分别是76.6%、75.0%。CEA+SCC+CYFRA21-1+NSE+影像学联合检测的误诊率最低,为0.82%。结论:肿瘤标志物和肺部影像学的联合检测在早期诊断肺癌中有着极其重要的临床意义,可以显著降低误诊率。

Objective Our retrospective study was aimed toanalyze the clinical significance of combined detection of multiple tumor markers and pulmonary imaging in early diagnosing patients with lung cancer. Methods Clinical data of 150 patients with lung cancerreceived treatment at our hospitalwas retrospectivelyanalyzed. 70 patients with benign disease at the same time at our hospital were chosen as the lung benign disease group. 52 healthy persons at the same time at our hospital were chosen as the control group. The detective results of 5 kinds of tumor markers of patients in three groups, the sensitivity and specificity of tumor markers, the sensitivity of combined detection of various indicators were compared. Results The levels of NSE, CEA and CYFRA21-1 of patients in lung cancer group were all higher than those in lung benign disease group and control group. The value of SCC in lung cancer group was higher than that in control group. The specificity of every tumor marker was high. The sensitivity of CEA was the highest(63.8%), and followed by CYFRA21-1(44.1%). The negative, positive predictive value of CEA were the highest, they were 76.6%,75.0%. The sensitivity of combined detection of CEA+SCC+ CYFRA21-1+NSE+ iconography were the highest(90.6%). Conclusion The combined detection of multiple tumor markers and pulmonary imaging plays an important role in early diagnosing lung cancer.