ICH患者血清和血肿液中IL-4、IL-6、IL-8、IL-10的变化研究

Hematoma fluid and serum of patients with acute cerebral hemorrhage about IL-4, IL-6, IL-8, and IL-10 Changes

目的 :观察急性脑出血(ICH)患者血清和血肿液中IL-4、IL-6、IL-8、IL-10的变化。方法 :选取80例在我院治疗的基底节区脑出血患者,按照发病时间将患者分为5组(发病时间≤6 h、6h<发病时间≤12h、12h<发病时间≤24 h、24h<发病时间≤72 h、3d<发病时间≤7 d),检测各组血清和血肿液中IL-4、IL-6、IL-8、IL-10的含量以及出血量和水肿量;另选取21例健康体检者,检测其血清IL-4、IL-6、IL-8、IL-10的含量作对照。结果 :IL-4、IL-6、IL-8、IL-10在患者静脉血、血肿液中的浓度均显著高于正常对照组,而患者静脉血与血肿液中IL-4、IL-6、IL-8、IL-10浓度比较,差异无统计学意义。基底节区脑出血患者发病时间≤6 h与正常对照组比较,除IL-10浓度升高不明显外,IL-4、IL-6、IL-8浓度均明显升高;24h<发病时间≤72 h时,IL-4、IL-6、IL-8浓度与其他各时段比较,以及3d<发病时间≤7 d时,IL-10浓度与其他各时段比较,差异均具有统计学意义。各时段出血量和水肿量比较,差异均无统计学意义,出血量和水肿量均在发病时间≤6 h至12h<发病时间≤24 h逐渐增大,12h<发病时间≤24 h达到峰值。结论 :ICH患者静脉血、血肿液中IL-4、IL-6、IL-8浓度可以作为早期检测(≤6h)ICH的指标,并可通过不同炎症因子的含量变化判断ICH患者发病时间,且患者发病一周内周围脑组织出血量和水肿量变化不大。

Objective To observe the changes of IL-4, IL-6, IL-8, IL-10 in serum and hematoma of ICH. Methods 80 cases ICH patients were divided into five groups(<6h, 6-12 h, 12-24 h, 24-72 h, 3-7d). The control group were 21 healthy persons serum. The content of IL-4, IL-6, IL-8, IL-10 in different time were compared and the amount of bleeding and edema. Results IL-4, IL-6, IL-8, IL-10 in patients with venous hematoma fluid concentrations were significantly higher than the control group), while patients with venous hematoma fluid IL-4, IL-6, IL-8, IL 10-concentration, the difference was not statistically significant. Basal ganglia hemorrhage onset time of ≤6 h compared with the control group, in addition to elevated concentrations of IL 10-obvious external, IL-4, IL-6,-8 IL concentrations were significantly increased; 24 h <onset time ≤72 h, IL-4, IL-6, IL-8 concentration in comparison with other all time, and 3d <onset ≤7 d when, IL 10-times the concentration of each other, the difference was statistically significant. Each time the amount of bleeding and edema, the difference was not statistically significant, the amount of bleeding and edema volume in the onset time ≤6 h to 12 h <onset ≤24 h increases, 12 h <onset ≤ 24 h peak. Conclusion The content of IL-4, IL-6, IL-8, IL-10 can be used as an indicator for early detection of ICH in the 24-72 h.