替格瑞洛治疗不稳定型心绞痛的临床疗效研究

Effect of Ti Gray Lo on the treatment of unstable angina patients

目的 :观察替格瑞洛应用于接受PCI介入治疗的不稳定型心绞痛患者的临床效果。方法 :将85于我院接受介入治疗的不稳定型心绞痛患者随机分为观察组和对照组。对照组给予氯吡格雷治疗,研究组给予替格瑞洛治疗。观察治疗随访至6个月。比较2组患者治疗前及治疗后12 h、7 d、1个月的C-反应蛋白(CRP)、白细胞介素-6(IL-6)、髓过氧物酶(MPO)的变化,术后半年时进行CAG及IVUS检查,了解患者支架内再狭窄的发生情况。比较2组患者的临床疗效以及不良反应的发生情况。结果 :观察组临床疗效显效、有效及无效比例分别是35、6、4例,好于对照组比例(24、6、10例)。观察患者的CRP、IL-6、MPO低于对照组,支架内再狭窄的发生率也低于对照组。两组患者药物的不良反应出血、呼吸困难未表现出明显的区别。结论 :与氯吡格雷相比,替格瑞洛具有更好的抑制炎症的效果,ISR的发生率也低。

Objective To observe the effect of ticagrelor should be used for patients with unstable angina PCI intervention effect. Methods 85 patients with unstable angina pectoris were randomly divided into observation group and control group. The patients were treated with. The control group was treated with Gray. The control group was treated with Ti Gerui. The patients were treated with 12 h,CAG(CRP),interleukin 6(IL 6),2015-04(MPO),two days after treatment,C,IVUS,ISR,7 days,January. Results the incidence of ISR,IL-6 and CRP in the observation group was lower than that of the control group,and the incidence of P<0.05 was lower than that of the control group,MPO. Conclusion compared Luotong Grenada for Grey,inhibition of inflammation has better effect,the incidence of ISR is low.