不同治疗策略对晚期肺癌患者临床疗效观察

Effects of different treatment strategies on the levels of CEA, CA125, CYFRA21-1, NSE, and survival rate of patients with advanced lung cancer

目的 :探讨不同治疗策略用于晚期肺癌患者的临床疗效。方法 :回顾性分析我院收治没有手术指征的晚期肺癌及术后复发的患者,随机分成全剂量化疗、姑息化疗及对症支持三组,给予不同的治疗策略,评估治疗期间的不良反应、生活质量和临床疗效,对生存期进行随访。结果 :针对血清肿瘤标志物水平,全剂量化疗组术后下降明显,姑息化疗组略微下降,而对症支持组基本无降低,甚至有部分升高。在不良反应和生活质量方面,全剂量化疗组副作用大,远期生存时间最差,姑息化疗组影响不大,明显提升生存时间,对症支持组生存时间次之。结论 :对于晚期无手术指征肺癌患者及术后复发患者,姑息化疗临床疗效更优,临床上应尽量选用该治疗方案。

Objective To analysis the clinical effect of different treatment strategies for patients with advanced lung cancer. Methods A retrospective analysis of our hospital not surgical patients who relapsed after syndrome in patients with advanced lung cancer and surgery were randomly divided into three groups, namely full dose chemotherapy group, palliative chemotherapy group and symptomatic support group. These groups were given different treatment strategies to evaluate adverse reactions, clinical effect, quality of life and survival. Results for serum tumor marker detection results, the serum levels of tumor mark level in full dose chemotherapy group compared with those before decreased significantly, palliative chemotherapy group decreased slightly and supportive group did not decrease, and the rise of the portion of the phenomenon. Due to side effects, survival time in the full dose chemotherapy group was the shortest, palliative chemotherapy has significantly elevated survival time, symptomatic and supportive group had little effect. Conclusion Palliative chemotherapy is more effective in the treatment of patients with advanced lung cancer and postoperative recurrence. In clinical practice, we should try to choose palliative chemotherapy.