脑神经生长素对新生儿缺氧缺血性脑损伤的保护作用

Protective effect of brain nerve growth factor on neonatal hypoxic ischemic brain injury

目的 :探讨脑神经生长素对新生儿缺血缺氧性脑病(HIE)脑损伤的保护作用。方法 :选取本院新生儿科收治的98例HIE新生儿采用随机数字表法分为试验组和对照组各49例,两组患儿均采用常规治疗,试验组加用脑神经生长素治疗,两组患者均治疗7d后观察临床效果。结果 :治疗后第7d、第14d两组患儿的NBNA评分均显著高于治疗第1d和对照组;试验组患儿治疗3个月、6个月的MDI、PDI评分均显著的高于对照组患儿;试验组患儿治疗有效率81.63%显著高于对照组的63.27%。结论 :脑神经生长素辅助常规疗法对HIE患儿脑损伤具有显著的保护作用,有利于患儿远期智能发育。

Objective To study the protective effect of CNG on neonatal hypoxic-ischemic encephalopathy(HIE)brain injury. Methods Select the hospital treated 98 cases of neonatal HIE newborns were randomly assigned into experimental group and control group 49 cases, two groups of children were with conventional treatment, the test group were treated with cranial nerve growth hormone, two groups of patients The clinical effects were observed after treatment 7d. Results Article 7d, Section 14 d of the two groups of children NBNA scores were significantly improved after treatment in this group of treatment compared 1d, after treatment 7d, 14 d test group of children NBNA scores were significantly higher than; test group of children treated for 3 months, 6 months, MDI, PDI scores were significantly higher in children; treatment of children test group was significantly higher 81.63% to 63.27% in the control group; there are a total efficiency of two groups of children showed no significant difference. Conclusion CNG assist conventional therapy for HIE children with brain injury have a significant protective effect, in favor of long-term intellectual development of children.