后腹腔镜下肾部分切除术联合过继免疫疗法应用于肾癌的疗效分析

Analysis the effect of Laparoscopic partial nephrectomy combined with adoptive immunotherapy therapy for treatment of kidney cancer

目的 :探讨后腹腔镜下肾部分切除术联合过继免疫疗法应用于肾癌的疗效。方法 :选取我院收治的90例后腹腔镜肾部分切除术后病理确诊为肾透明细胞癌患者,将其随机分为观察组和对照组,观察组接受术后常规治疗联合过继免疫治疗,对照组术后接受常规治疗联合细胞因子治疗,比较两组治疗前后的免疫指标、临床指标变化。结果 :治疗前两组患者的白细胞、转氨酶、尿素氮以及肌酐水平比较无明显差异,治疗后对照组的白细胞较治疗前明显升高,转氨酶明显下降,且与观察组比较有明显差异。治疗前两组患者的CD3+、CD4+、CD8+、CD4+/CD8+、NK指标比较无明显差异,治疗后观察组的CD3+、CD4+、CD4+/CD8+、NK与治疗前相比均明显升高,与对照组相比有明显差异。结论 :腹腔镜肾部分切除术后采用过继免疫疗法治疗能够有效提高治疗效果,增强机体免疫功能,且不良反应较小,值得推广应用。

Objective To study the effect of Laparoscopic partial nephrectomy combined with adoptive immunotherapy therapy for treatment of kidney cancer. Methods Chose 90 cases of renal clear cell carcinoma patients in our hospital, randomly divided them into observation group and control group, observation group received conventional treatment combined with postoperative adoptive immunotherapy, control group received routine postoperative combined with cytokines therapy, compare the change of immune indexes, clinical indicators before and after treatment in two groups. Results White blood cells, transaminase, urea nitrogen and creatinine level had no significant difference between two groups before treatment, white blood cells significantly increased and the aminotransferase decreased obviously in the control group after treatment, and have obvious differences compared with the observation group. CD3 +, CD4 +, CD8 +, CD4 +/CD8 + and NK index had no significant difference between two groups before treatment, CD3 +, CD4 +, CD4 +/CD8 + and NK in the observation group after treatment were significantly higher compared with before treatment, have obvious differences compared with control group. Conclusion Laparoscopic partial nephrectomy combine adoptive immunity therapy can effectively improve the effect of treatment, enhance the body’s immune function, and has less adverse reactions, is worthy of popularization and application.