颈动脉狭窄与短暂性脑缺血发作认知功能损伤的相关性研究

The research on relevance between Carotid stenosis and cognitive function of the patients with transient ischemic attack

目的 :探索颈动脉狭窄与短暂性脑缺血发作认知功能的相关性。方法 :分析2013年1月~2014年12月在我院被诊断为短暂性脑缺血治疗并伴有颈动脉狭窄患者的临床资料,设为观察组。入院后诊断为单纯短暂性脑缺血的患者纳为对照组。结果 :观察组受试者MMSE、Mo CA、CCSE评分均小于对照组;观察组中、重度患者TIA多次发作的比例较发作一次的比例较高;观察组中TIA伴有颈静脉狭窄的患者N2、P300的潜伏期明显高于对照组患者的潜伏期水平;观察组波幅明显低于对照组。结论 :TIA伴颈动脉狭窄患者的认知能力较单纯TIA患者损害严重,且TIA发作频次越多,血管狭窄程度越重,认知障碍越明显。

Objective To investigate relevance between Carotid stenosis and cognitive function of the patients with transient ischemic attack. Methods Analyzing the clinical data of the patients who were as transient ischemic treatment and carotid artery stenosis from January 2013 to December 2014 in our hospital, set as observation group. The patients who were diagnosed as transient ischemic after admission, set as control group. Results The patients' MMSE, Mo CA CCSE score in observation group is less than the control group, the difference is statistically significant; In the observation group, the proportion of severe patients with TIA multi-episode attacks a higher percentage of statistically significant difference; the patients of TIA with carotid stenosis in observation group N2, latency of P300 was obviously higher than that of control group in the patient's level of the incubation period, the difference is statistically significant. Amplitude of observation group was obviously lower than the control group, the difference statistically significant. Conclusions The cognitive ability of TIA patients with carotid stenosis had much serious damage than TIA patients without no symptom, and the more frequency of TIA, the more heavier of the degree of carotid stenosis, the cognitive damage is the more obvious.