阿司匹林在有脑出血史缺血性脑卒中复发患者中的预防应用

Preventive effects of application of aspirin on the recurrence of patients with ischemic stroke complicated with cerebral hemorrhage history

目的 :观察和分析阿司匹林在有脑出血(CH)史缺血性脑卒中(IS)复发患者中的预防效果及安全性。方法:选取100例具有CH史的IS患者作为观察组,选取100例无CH史的IS患者作为对照组,对两组患者均在常规疗法的基础上给予阿司匹林抗血小板治疗,对两组患者治疗前、治疗后1周、治疗后1个月、治疗后6个月的血脂指标、临床疗效及并发症发生情况进行观察和比较。结果 :从治疗后1周开始,两组患者的各项血脂指标均较治疗前有了显著的改善,而两组患者各项血脂指标的组间差异、疗效构成和临床有效率的差异均无统计学意义;观察组患者并发症的总发生率显著高于对照组,但两组患者各项并发症的发生率的差异均无统计学意义。结论 :对于具有CH病史的IS患者应用阿司匹林抗血小板治疗,其临床疗效与在初发IS患者中应用时基本等同,而且不会显著增加IS和CH的复发率,具有较好的安全性。

Objective To observe and analyze the preventive effects and safety of application of aspirin on the recurrence of patients with ischemic stroke(IS) complicated with cerebral hemorrhage(CH) history. Methods 100 cases of the patients with IS complicated with CH history were selected as the observation group. 100 cases of the patients with IS without CH history were selected as the control group. The patients in the two groups were treated with aspirin on the basis of conventional therapy. The blood lipids indexes before the treatment and after the 1st week, the 1st month, the 6th month, and the clinical efficacy and the complications of the patients in the two groups were observed and compared. Results From the 1st week after the treatment, the blood lipid indexes of patients in the two groups significantly improved compared with those before the treatment. However, there were no statistical significant differences of the blood lipid indexes, the therapeutic effects distribution, the clinical efficiency between the patients in the two groups; The overall incidence of the complications of the patients in the observation group was significantly higher than that in the control group. However, there were no statistically significant differences of various complications between the patients in the two groups. Conclusion The clinical efficacy of aspirin antiplatelet therapy in IS patients with a history of CH was equal to that of IS patients. The application wound not increase significantly the recurrence rate of CH and IS, and has high safety.