维持性血液透析患者不同血红蛋白水平与住院率、心血管事件的相关性分析

Correlation analysis between different hemoglobin levels and hospitalization rate and cardiovascular events in maintenance hemodialysis patients

目的 :探讨维持性血液透析(MHD)患者不同血红蛋白(Hb)水平与住院率、心血管事件的关系。方法 :选择我院血透室治疗的306例MHD患者为研究对象,随机将患者分析三组,每组102例,分别制定高中低不同的血红蛋白水平,即A组Hb水平为95~110g/L,B组Hb水平为110~125g/L,C组Hb水平为Hb125~140g/L,患者Hb达标后进行为期18个月的随访,比较三组患者住院率及心血管事件发生率。结果 :随访期间,共有123例患者住院,占40.20%,其中心血管事件54例(17.65%);A组患者住院率及心血管事件发生率分别为58.22%和32.35%,明显高于B组(26.47%、8.82%)、C组(35.29%、11.76%),差异有统计学意义;B组患者住院率及心血管事件发生率与C组比较,差异无统计学意义。结论 :维持性性血液透析患者的血红蛋白控制水平在110~125g/L时具有较好的安全性和有效性。

Objective To investigate the relationship between different hemoglobin(Hb)levels and the rate of hospitalization and cardiovascular events in patients with maintenance hemodialysis(MHD). Methods 306 cases of MHD patients treated in our hospital as the research object, they were randomly divided into three groups, 102 cases in each group, different hemoglobin(Hb)levels of high, middle and low target were formulated, group A for 95 ~ 110g/L, group B for 110 ~ 125g/L, group C for 125~140g/L, when Hb standards were achieved, they were followed up for 18 months, the hospitalized and cardiovascular events rate in three groups were compared. Results During the follow-up period, there were of 123 cases(40.20%)of hospitalized patients, including 54 cases(17.65%)of cardiovascular events; The hospitalized rate and cardiovascular events rate in group A(58.22% and 32.35%)was significantly higher than that in group B(26.47%, 8.82%)and group C(35.29%, 11.76%), the difference was of statistically significant; there were of no statistically significant difference between group B and group C. Conclusion The hemoglobin control level of 110 ~ 125g/L in maintenance hemodialysis patients is safe and effective.