妊娠期高血压综合征孕妇骨代谢变化的临床意义

Clinical significance of the changes of bone metabolism in pregnant women with pregnancy induced hypertension

目的:探讨妊娠期高血压综合征(简称妊高症)孕妇骨代谢变化的临床意义。方法:回顾性分析于我院妇产科建档的62例妊高症孕妇(妊高症组,n=62)和62例正常妊娠孕妇(正常妊娠组,n=62)临床资料。对比两组孕妇骨代谢指标[血清钙(Ca)、磷(P)、降钙素(CT)、骨钙素(BGP)]、血小板参数[血小板计数(PLT)、血小板平均体积(MPV)、血小板分布宽度(PDW)]及血液流变学指标(全血黏度、血浆黏度)差异。结果:正常妊娠组孕妇血清Ca[(2.41±0.23)mmol/L]、CT[(62.34±15.34)ng/L]、BGP[(5.23±0.78)μg/L]等骨代谢指标检测结果及PLT[(172.96±33.63)×109/L]水平均显著高于妊高症组孕妇[(2.19±0.25)mmol/L、(43.52±12.55)ng/L、(3.63±0.91)μg/L和(147.92±26.35)×109/L],MPV[(9.23±1.20)fl]、PDW[(19.25±1.02)%]等血小板参数检测结果,全血粘度[(8.82±1.29)η/m Pa·s、(5.20±0.51)η/m Pa·s、(4.23±0.59)η/m Pa·s]、血浆粘度[(1.62±0.28)η/m Pa·s]等血液流变学指标检测结果及血清P[(1.21±0.08)mmol/L]水平则显著低于妊高症组,差异均有统计学意义。结论:妊高症孕妇相较于正常孕妇存在骨代谢、血小板参数及血液流变学状态异常情况,需引起临床重视。

Objective To investigate the clinical significance of changes of bone metabolism in pregnant women with pregnancy induced hypertension(PIH). Methods The clinical data of 62 pregnant women who had bookbuilding(PIH group, n = 62) and 62 normal pregnant women(normal pregnancy group, n = 62) in the department of gynaecology and obstetricswere retrospectively analyzed. The bone metabolism indexes[serum calcium(Ca), phosphorus(P), calcitonin(CT), bone gla protein(BGP) ], platelet parameters [platelet count(PLT), mean platelet volume(MPV), platelet distribution width(PDW) ] and hemodynamic indexes(whole blood viscosity, plasma viscosity) were compared between the two groups. Results The levels of bone metabolism indexes such as serum Ca [(2.41±0.23) mmol/L], CT[(62.34±15.34) ng/L] and BGP[(5.23±0.78) μg/L] and PLT level [(172.96±33.63) ×109/L] in the normal pregnancy group were significantly higher than those in PIH group [(2.19±0.25) mmol/L,(43.52±12.55) ng/L,(3.63±0.91) μg/L,(147.92±26.35) ×109/L] while MPV [(9.23±1.20) fl], PDW[(19.25±1.02) %], whole blood viscosity [(8.82±1.29) η/m Pa·s,(5.20±0.51) η/m Pa·s,(4.23±0.59) η/m Pa·s] and plasma viscosity [(1.62±0.28) η/m Pa·s] were significantly lower than those in PIH group. Conclusion Compared with normal pregnant women, pregnant women with PIH have abnormal conditions of bone metabolism, platelet parameters and hemodynamic abnormalities, which needs clinical attention.