Hp感染对冠心病患者冠状动脉粥样硬化进展的作用分析

The effect of Hp infection on the progress of coronary atherosclerosis in patients with coronary heart disease

目的:分析幽门螺杆菌(Hp)感染对冠心病患者冠状动脉粥样硬化进展的作用。方法:以2012年1月~2015年6月确诊的100例冠心病患者为研究对象,依据14C尿素呼气试验结果将其分为观察组(Hp感染)与对照组(非Hp感染),对两组血脂指标、血清氧化低密度脂蛋白(ox LDL)、超敏C反应蛋白(hs-CRP)、颈动脉内中膜厚度、踝臂指数(ABI)、脉搏波传导速度(PWV)检测比较。结果:与对照组比较,观察组TC、TG、LDL-C、血浆hsCRP、血清ox LDL、CCA-IMT、CB-IMT、CCI-IMT及PWV均显著高,ABI显著低,两组比较差异均有统计学意义。结论:Hp感染可能是通过影响机体脂质代谢、引发炎症反应、提高ox LDL水平引发颈动脉内中膜增厚、粥样斑块不稳定,达到促冠心病发生、发展的目的。

Objective To analyze the effect of Helicobacter pylori(Hp) infection on the progress of coronary atherosclerosis in patients with coronary heart disease(CHD). Methods One hundred patients with coronary heart disease confirmed between January 2012 and June 2015 were studied. According to the results of 14 C urea breath test, they were divided into observation group(with Hp infection) and control group(without Hp infection). The serum lipid parameters, serum oxidized low density lipoprotein(ox LDL), high-sensitivity C reactive protein(hs-CRP), carotid intima-media thickness, ankle brachial index(ABI), pulse wave velocity(PWV) were compared between the two groups. Results Compared with the control group, TC, TG, LDL-C, plasma hs-CRP, serum ox LDL,, CCA-IMT, CB-IMT, CCI-IMT and PWV in the observation group were significantly higher while ABI was significantly lower. Conclusion Hp infection may achieve the purpose of promoting the occurrence and development ofcoronary artery diseaseby influencing lipid metabolism, causing inflammation, improve ox LDL level and causing carotid intima-media thickening and unstable plaque instability.