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VEGF在AECOPD并发呼吸衰竭诊断及预后判定中的作用分析 被引量:1

The role of VEGF in the diagnosis and prognosis of AECOPD complicated with respiratory failure
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摘要 目的:探讨急性加重期慢性阻塞性肺疾病(AECOPD)并发呼吸衰竭患者的血管内皮生长因子(VEGF)水平变化,并分析其在疾病诊断和预后中的判断作用。方法:回顾性分析2015年3月~2016年10月在我院接受治疗的AECOPD并发呼吸衰竭患者的临床资料,根据其预后分为好转组和死亡组。观察好转组和死亡组患者血清炎症因子、血气指标、VEGF、肺功能的差异,分析AECOPD患者VEGF水平与血清炎症因子、血气指标、肺功能的相关性。结果:死亡组患者的IL-8、CRP和VEGF水平均高于好转组;死亡组患者SpO_2水平低于好转组,PaCO_2水平高于好转组;死亡组患者FVC、FEV1、MMEF和PEF水平低于好转组;AECOPD患者的VEGF水平与IL-8、CRP、PaCO_2水平正相关,与SpO_2、FVC、FEV1、MMEF和PEF水平负相关。结论:AECOPD并发呼吸衰竭患者的VEGF水平较高,且与患者的炎症因子和肺功能指标密切相关。 Objective To investigate the acute exacerbation of chronic obstructive pulmonary disease(AECOPD) patients with respiratory failure complicated by vascular endothelial growth factor(VEGF) levels, and to analyze its role in disease diagnosis and prognosis judgement. Methods The clinical data of patients with AECOPD complicated with respiratory failure treated in our hospital from March 2015 to October 2016 were retrospectively analyzed. The differences of serum levels of inflammatory factors, blood gas indexes, VEGF and pulmonary function in the patients in the improvement group and the death group were observed. The correlation between VEGF level and serum inflammatory factors, blood gas and pulmonary function in patients with AECOPD was analyzed. Results The death group of patients with IL-8, CRP and VEGF levels were higher than the improved group; The SpO_2 level in the death group was lower than that in the improved group, and the level of PaCO_2 was higher than that of the improvement group; The levels of FVC, FEV1, MMEF and PEF in the death group were lower than those in the improvement group; The level of VEGF in patients with AECOPD was positively correlated with IL-8, CRP and PaCO_2, and negatively correlated with SpO_2, FVC, FEV1, MMEF and PEF. Conclusion The level of VEGF in patients with AECOPD complicated with respiratory failure is high, and is closely related to the inflammatory factors and pulmonary function indexes.
出处 《湖南师范大学学报(医学版)》 2017年第5期173-175,共3页 Journal of Hunan Normal University(Medical Sciences)
关键词 慢性阻塞性肺疾病 血管内皮生长因子 炎症因子 肺功能 chronic obstructive pulmonary disease vascular endothelial growth factor inflammatory factor lung function
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